Familial tranmission of genitovaginal prolapse
Familial tranmission of genitovaginal prolapse
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DOI：
10.1007/s00192-005-0054-x
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发表时间：
2006-10-01
影响因子：
1.8
通讯作者：
Rodriguez, Larissa V.
中科院分区：
文献类型：
--
作者：
Jack, Gregory S.;Nikolova, Ganka;Rodriguez, Larissa V.
一些女性很少或没有风险因素发展脱垂，而其他女性有多种风险因素没有。似乎有些妇女在同等危险因素的情况下可能有脱垂的倾向。我们确定了10名年龄小于55岁的患者，有脱垂家族史。她们的平均年龄为37岁（范围27-51），平均分娩次数为1.8，平均出生体重为8磅。遗传分析表明，这些家庭内的遗传模式表明，盆腔器官脱垂分离在一个占主导地位的方式与不完全脱垂在这些家庭。观察到母亲和父亲的传播。受影响患者的兄弟姐妹的相对风险是一般人群风险的五倍。对这些家庭的进一步调查可能会发现导致脱垂的遗传缺陷。
Some females with little to no risk factors develop prolapse, while other females with multiple risk factors do not. It appears that some women may have a predisposition for prolapse in the setting of equivalent risk factors. We identified 10 patients younger than 55 years old with a family history of prolapse. Their average age was 37 years (range 27-51), the mean number of deliveries was 1.8, and their mean birth weight was 8 lbs. Genetic analysis of the inheritance pattern within these families demonstrated that pelvic organ prolapse segregated in a dominant fashion with incomplete penetrance in these families. Both maternal and paternal transmissions were observed. The relative risk to siblings of affected patients was five times that of the risk for the general population. Further investigation of these families may identify a genetic defect responsible for prolapse.