Fast temporal response fiber-optic chemical sensors based on the photodeposition of micrometer-scale polymer arrays.
Fast temporal response fiber-optic chemical sensors based on the photodeposition of micrometer-scale polymer arrays.
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DOI：
10.1021/ac961058s
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发表时间：
1997-06
影响因子：
7.4
通讯作者：
B. Healey;D. Walt
中科院分区：
文献类型：
--
作者：
B. Healey;D. Walt
用于检测pH和O2的光纤化学传感器微阵列已经开发出亚秒级响应时间。传感器微阵列是通过共价固定（pH传感器阵列）或物理截留（O2传感器阵列）的光沉积聚合物基质上的光学成像纤维的荧光指示剂。聚合物微阵列由成千上万个单独的元件组成，这些元件被光沉积为半球，使得传感器阵列的每个元件直接耦合到成像光纤的离散光学元件，并且不与其他相邻元件接触。由于半球形形状和阵列元件的个体性，分析物到传感器元件的扩散主要是径向扩散，导致快速响应时间。基于荧光素的pH敏感阵列在300 ms内响应1.5单位的pH变化，而O2敏感阵列在200 ms内响应O2变化（稳态响应的90%）。
Fiber-optic chemical sensor microarrays for the detection of pH and O2 have been developed with subsecond response times. Sensor microarrays are fabricated by the covalent immobilization (pH sensor arrays) or the physical entrapment (O2 sensor arrays) of fluorescent indicators in photodeposited polymer matrices on optical imaging fibers. Polymer microarrays are comprised of thousands of individual elements photodeposited as hemispheres such that each element of the sensor array is coupled directly to a discrete optical element of the imaging fiber and is not in contact with other neighboring elements. Because of the hemispherical shape and the individuality of the array elements, diffusion of analyte to the sensor elements is dominated by radial diffusion, resulting in a rapid response time. pH-sensitive arrays based on fluorescein respond to a 1.5-unit pH change within 300 ms, while the O2-sensitive arrays respond to O2 changes within 200 ms (90% of steady state response).