Evaluation of the Potential Use of Trabecular Bone Score to Complement Bone Mineral Density in the Diagnosis of Osteoporosis: A Preliminary Spine BMD-Matched, Case-Control Study
Evaluation of the Potential Use of Trabecular Bone Score to Complement Bone Mineral Density in the Diagnosis of Osteoporosis: A Preliminary Spine BMD-Matched, Case-Control Study
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DOI：
10.1016/j.jocd.2008.11.006
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发表时间：
2009-04-01
影响因子：
2.5
通讯作者：
Hans, Didier
中科院分区：
文献类型：
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作者：
Pothuaud, Laurent;Barthe, Nicole;Hans, Didier
骨小梁评分(TBS)是通过对双能X线骨密度仪(DXA)图像进行灰度化分析而确定的新参数。它依赖于松质骨微结构的平均厚度和体积分数。这是一项初步的病例对照研究，旨在评估TBS作为骨密度(BMD)补充指标的潜在诊断价值。通过比较有无骨折的绝经后妇女。样本包括45名患有骨质疏松性骨折的女性(5名髋部骨折，20名脊椎骨折，20名其他类型的骨折)和155名没有骨折的女性。考虑到每种类型的骨折(髋部除外)，进行了分层，有骨折和没有骨折的妇女在年龄和脊柱骨密度方面进行了匹配。在全脊柱测量BMD和TBS。在全脊柱测量的TBS显示，当考虑到所有类型的骨折和脊椎骨折时，骨折组与年龄和脊柱骨密度匹配的非骨折组之间存在显著差异。在这些病例中，联合检测BMD和TBS的诊断价值可能比单独检测BMD更高。从标准的DXA直接扫描评估，TBS在检测骨质疏松性骨折方面潜在地补充了骨密度。有必要进行前瞻性研究，以充分评估TBS作为骨折的补充危险因素的潜在作用。
The trabecular bone score (TBS) is a new parameter that is determined from gray-level analysis of dual-energy X-ray absorptiometry (DXA) images. It relies on the mean thickness and volume fraction of trabecular bone micro-architecture. This was a preliminary case-control study to evaluate the potential diagnostic value of TBS as a complement to bone mineral density (BMD). by comparing postmenopausal women with and without fractures. The sample consisted of 45 women with osteoporotic fractures (5 hip fractures, 20 vertebral fractures, and 20 other types of fracture) and 155 women without a fracture. Stratification was performed, taking into account each type of fracture (except hip), and women with and without fractures were matched for age and spine BMD. BMD and TBS were measured at the total spine. TBS measured at the total spine revealed a significant difference between the fracture and age- and spine BMD-matched nonfracture group, when considering all types of fractures and vertebral fractures. In these cases, the diagnostic value of the combination of BMD and TBS likely will be higher compared with that of BMD alone. TBS, as evaluated from standard DXA scans directly, potentially complements BMD in the detection of osteoporotic fractures. Prospective studies are necessary to fully evaluate the potential role of TBS as a complementary risk factor for fracture.