Low urinary 6-sulfatoxymelatonin levels in patients with severe congestive heart failure
Low urinary 6-sulfatoxymelatonin levels in patients with severe congestive heart failure
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DOI：
10.1385/endo:22:3:245
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发表时间：
2003-12-01
期刊：
影响因子：
3.7
通讯作者：
Cardinali, DP
中科院分区：
文献类型：
--
作者：
Girotti, L;Lago, M;Cardinali, DP
目的：探讨充血性心力衰竭（CHF）患者尿中6-硫酸氧褪黑激素（6-sulfatoxymelatonin，6-SH）的排泄情况。研究方法：采用放射免疫分析法测定33例CHF住院患者和146例健康志愿者尿6-硫酸氧褪黑激素。从样本中排除患有肝或肾衰竭的个体。数据采用Mann-Whitney检验和回归分析。结果：CHF患者的6-硫酸氧褪黑激素水平显著低于对照组（中位数2.6 μ g vs 6.02 μ g，p < 0.0001）。无论使用β-肾上腺素能受体阻滞剂或苯二氮卓类药物，均观察到该降低。随着年龄的增长，6-硫酸氧褪黑激素的排泄量显着减少。慢性和急性CHF患者尿6-硫酸氧褪黑激素水平无显著差异。结论：结果表明，循环褪黑激素水平较低的CHF患者。这种降低可能先于心力衰竭的加重。
Objective: To assess urinary 6-sulfatoxymelatonin excretion in patients admitted to the hospital because of congestive heart failure (CHF). Methods: Urinary 6-sulfatoxymelatonin was measured by a specific radioimmunoassay in 33 hospitalized patients with CHF and in 146 healthy ambulatory volunteers. Individuals with hepatic or renal failure were excluded from the sample. Data were analyzed by the Mann-Whitney test and regression analysis. Results: 6-Sulfatoxymelatonin levels were significantly lower in CHF patients than controls (median 2.6 vs 6.02 mug, p < 0.0001). This decrease was observed regardless of beta-adrenergic blocker or benzodiazepine medication. A significant decrease in 6-sulfatoxymellatonin excretion occurred with age. There were no significant differences in urinary 6-sulfatoxymelatonin levels between chronic and acute CHF patients. Conclusions: The results suggest that circulating melatonin levels are low in patients with CHF. Such a decrease may precede aggravation of heart failure.