STIMULATION OF INTERLEUKIN-6 PRODUCTION OF PERIODONTAL-LIGAMENT CELLS BY PORPHYROMONAS-ENDODONTALIS LIPOPOLYSACCHARIDE
STIMULATION OF INTERLEUKIN-6 PRODUCTION OF PERIODONTAL-LIGAMENT CELLS BY PORPHYROMONAS-ENDODONTALIS LIPOPOLYSACCHARIDE
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DOI：
10.1006/bmmb.1994.1068
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发表时间：
1994-12-01
期刊：
影响因子：
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通讯作者：
ABIKO, Y
中科院分区：
文献类型：
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作者：
OGURA, N;SHIBATA, Y;ABIKO, Y
白细胞介素-6（IL-6）是一种多功能细胞因子，在急性和慢性炎症中起重要作用，也可能与骨吸收有关。我们研究了IL-6在牙周膜（PDL）细胞，这是处理与脂多糖（LPS）从几个口腔炎性病原体的生产。从感染的根管和根囊肿液中分离的牙髓卟啉单胞菌的LPS比检查的任何其他牙周生物的LPS更有效。牙髓毕赤酵母LPS以时间和剂量依赖性方式刺激PDL细胞释放IL-6。北方杂交结果显示，牙周膜细胞IL-6 mRNA表达水平在LPS作用下明显升高。这些结果表明，刺激IL-6释放的PDL细胞的牙髓P. endodontalis LPS可能在炎症和牙槽骨吸收的牙周和根尖周疾病的进展中发挥作用。(C)1994年出版社出版。
Interleukin-6 (IL-6), which is a multifunctional cytokine, has important roles in acute and chronic inflammation and may also be implicated in bone resorption. We examined the IL-6 production in periodontal ligament (PDL) cells which were treated with lipopolysaccharide (LPS) from several oral inflammatory pathogens. The LPS from Porphyromonas endodontalis, which was isolated from infected root canals and radicular cyst fluids, was more potent than the LPS from any other periodontal organisms examined. P. endodontalis LPS stimulated IL-6 release from PDL cells in a time- and dose dependent manner. Northern blot hybridization analysis revealed that the IL-6 mRNA level in PDL cells was increased by P. endodontalis LPS. These results suggest that stimulation of the IL-6 release of PDL cells by P. endodontalis LPS may have a role in the progression of inflammation and alveolar bone resorption in periodontal and periapical diseases. (C) 1994 Academic Press, Inc.