The Colors of Mice: A Model Genetic Network
The Colors of Mice: A Model Genetic Network
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小鼠的颜色：遗传网络模型
DOI：
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发表时间：
2010
期刊：
影响因子：
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通讯作者：
D. Bennett
中科院分区：
文献类型：
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作者：
M. Lamoreux;V. Delmas;L. Larue;D. Bennett
前言。致谢。关于使用图片的声明。关于命名法的声明。第一部分：素描制度概论。1.素描系统概论。1.1.导言。1.2.脊椎动物的颜色。1.3.其他色素细胞。1.4.表皮黑色素单位。1.5.哺乳动物的毛发。1.6.黑素小体的生物发生和易位。1.7.黑色素。1.8.毛发生长。1.9.毛发生长周期。1.10.色素细胞谱系的胚胎发育。1.11.培养中的色素细胞。1.12。结论。附录：小鼠的颜色轨迹。第二部分：皮色轨迹。2.突变色素基因简介。2.1.正常黑素细胞发育的缺陷：随着年龄的增长出现白色斑点和灰白。2.2.正常黑素小体发育缺陷：白化病。2.3.黑素小体向其他细胞的运输：稀释型。2.4.色素类型转换：从黑色素生成到黑色素生成。3.白斑和渐进性灰化。3.1.定义和一般背景。3.2.色素细胞发育：发育生物学。3.3.黑素细胞的细胞信号通路。3.4.色素表型和经典的白斑基因。3.5.头部、心脏、耳朵和眼睛。4.白化病与正常黑素小体发育障碍。4.1.背景资料。4.2.黑素小体基质。4.3.催化黑色素生成的酶。4.4.调节黑素小体内部环境的膜蛋白。4.5.蛋白质的加工和传递到成熟的黑素小体。4.6.黑素小体运输。5.颜料型切换。5.1.导言。5.2.黄色表型。5.3.黑色素。5.4.黑素生成与真黑素/褐黑素的转换机制。5.5.在细胞水平上发出开关机制的信号。5.6.黄色基因。第三部分：技术和资源。6.通过基因操作产生的新的小鼠色素突变。6.1.导言。6.2.小鼠转基因：一代转基因小鼠。6.3.毛色转基因小鼠。6.4.通过基因打靶产生的毛色突变。6.5.遗传背景的影响。6.6.结论。7.其他物种和其他资源。7.1.导言。7.2.资源。7.3.其他物种。参考资料。索引。
Preface. Acknowledgments. Statement regarding the use of pictures. Statement regarding nomenclature. Part I: Introduction to the Pigmentary System. 1. Introduction to the Pigmentary System. 1.1. Introduction. 1.2. Colors of vertebrate animals. 1.3. Other pigment cells. 1.4. The epidermal melanin unit. 1.5. Mammalian hair. 1.6. Melanosome biogenesis and translocation. 1.7. Melanin. 1.8. Hair growth. 1.9. Hair growth cycles. 1.10. Embryonic development of the pigment cell lineage. 1.11. Pigment cells in culture. 1.12. Conclusion. Appendix: color loci of the mouse. Part II: The Pigmentary Loci. 2. Introduction to Mutant Pigmentary Genes. 2.1. Defects of normal melanocyte development: white spotting and graying with age. 2.2. Defects in normal melanosome development: albinism. 2.3. Transport of melanosomes to other cells: the dilute phenotype. 2.4. Pigment-type switching: from eumelanogenesis to pheomelanogenesis. 3. White Spotting and Progressive Graying. 3.1. Definitions and general background . 3.2. Pigment cell development: developmental biology. 3.3. Cellular signaling pathways for melanocytes. 3.4. Pigment phenotypes and the classical white-spotting genes. 3.5. The head, heart, ears, and eyes. 4. Albinism and the Failure of Normal Melanosome Development. 4.1. Background. 4.2. The melanosomal matrix. 4.3. The enzymes that catalyze melanogenesis. 4.4. Membrane proteins that regulate the internal milieu of the melanosome. 4.5. Protein processing and routing to the maturing melanosome. 4.6. Melanosome transport. 5. Pigment-Type Switching. 5.1. Introduction. 5.2. Yellow phenotypes. 5.3. Melanin pigment . 5.4. Melanogenesis and the eumelanin/pheomelanin switch mechanism. 5.5. Signaling the switch mechanism at the cellular level. 5.6. Yellow genes. Part III: Technology and Resources. 6. Novel Mouse Pigmentary Mutants Generated by Genetic Manipulation. 6.1. Introduction. 6.2. Mouse transgenesis: generation of genetically engineered mice. 6.3. Coat-color transgenic mice. 6.4. The coat-color mutants generated by gene targeting. 6.5. Influence of the genetic background. 6.6. Conclusions. 7. Other Species and Other Resources. 7.1. Introduction. 7.2. Resources. 7.3. Other species. References. Index.