In situ carcinoma developed over oral lichen planus: a case report with analysis of BUB3, p16, p53, Ki67 and SOX4 expression.
In situ carcinoma developed over oral lichen planus: a case report with analysis of BUB3, p16, p53, Ki67 and SOX4 expression.
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DOI：
10.1590/1678-775720150058
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发表时间：
2015-07
期刊：
影响因子：
--
通讯作者：
Amorim RF
中科院分区：
文献类型：
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作者：
Rosa EA;Lia EN;Macedo SB;Amorim RF
口腔扁平苔藓是一种常见的皮肤粘膜疾病。许多作者认为OLP具有恶性潜能;然而，涉及恶性转化的机制尚未阐明。摘要一位79岁男性患者，因口腔黏膜出现白色病灶五个月，诊断为口腔扁平苔藓。使用0.05%氯倍他索软膏治疗2个月后，皮损出现溃疡。对同一病变进行了新的活检，组织学分析显示为原位口腔癌（ISOC）。免疫组化显示，p16在OLP中表达阴性，而在ISOC中显示弱的胞浆染色。OLP和ISOC区域均存在强烈的核BUB 3染色。p53在两个区域中均显示较低强度的核染色。Ki 67在OLP区为阴性，而在ISOC区为核染色。SOX 4在两个研究区域均为阴性。BUB 3的表达，在这种情况下首次报告，和p16的表达可能表明这些基因的发病机制或恶性潜能的OLP的一些影响。
Oral lichen planus (OLP) represents a common mucocutaneous disease. Various authors have suggested that OLP has malignant potential; however, the mechanisms involved in malignant transformation have not yet been elucidated. A 79-year-old man presented a white lesion for five months in the buccal mucosa diagnosed as OLP. After two months using 0.05% clobetasol ointment for treatment, the lesion became ulcerated. A new biopsy of the same lesion was performed, and histological analysis showed an in situ oral carcinoma (ISOC). An immunohistochemistry panel was performed, and p16 expression was negative in OLP, however, it showed weak cytoplasmic staining in ISOC. There was strong nuclear BUB3 staining in both OLP and ISOC areas. p53 showed less intense nuclear staining in both regions. Ki67 was negative in OLP area, but showed nuclear staining in the ISOC. SOX4 was negative in both studied areas. BUB3 expression, first reported in this case, and the p16 expression may suggest some influence of these genes on pathogenesis or malignant potential of OLP.