Self-referential processing of negative stimuli within the ventral anterior cingulate gyrus and right amygdala
Self-referential processing of negative stimuli within the ventral anterior cingulate gyrus and right amygdala
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DOI：
10.1016/j.bandc.2008.07.010
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发表时间：
2009-02
影响因子：
2.5
通讯作者：
Shinpei Yoshimura;K. Ueda;Shin-ichi Suzuki;K. Onoda;Y. Okamoto;S. Yamawaki
中科院分区：
文献类型：
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作者：
Shinpei Yoshimura;K. Ueda;Shin-ichi Suzuki;K. Onoda;Y. Okamoto;S. Yamawaki
利用全脑功能磁共振成像（fMRI）研究了与情绪刺激自我参照加工相关的神经活动。15名健康被试在自我参照、他人参照、语义加工和字母加工四种条件下对积极和消极特质词进行判断。在消极词汇/自我参照条件下，右侧扣带回腹侧前部和右侧杏仁核活动显著；在积极词汇/自我参照条件下，左侧杏仁核活动显著。与语义加工组相比，自我参照组的前额叶内侧回、颞叶内侧回、扣带回后回和楔前叶的活动显著增加。这些结果表明，内侧前额叶回、扣带回后回和楔前叶与自我参照加工有关，而腹侧扣带回参与消极情绪刺激的自我参照加工。结果还表明，杏仁核与积极和消极情绪刺激的自我参照加工有关。
Neural activity associated with self-referential processing of emotional stimuli was investigated using whole brain functional magnetic resonance imaging (fMRI). Fifteen healthy subjects underwent fMRI scanning while making judgments about positive and negative trait words in four conditions (self-reference, other-reference, semantic processing, and letter processing). Significant activity was observed in the right ventral anterior cingulate gyrus and the right amygdala in the negative-word/self-reference condition, and in the left amygdala in the positive-word/self-reference condition. Compared with the semantic-processing condition, the self-reference conditions showed significantly more activity in the medial prefrontal and temporal gyri, posterior cingulate gyrus, and precuneus. These results suggest that the medial prefrontal gyrus, posterior cingulate gyrus, and precuneus are associated with a self-referential processing, and the ventral anterior cingulate gyrus is involved in self-referential processing of negative emotional stimuli. The results also suggest that the amygdala is associated with self-referential processing of both positive and negative emotional stimuli.