Alcohol consumption and plasma concentration of C-reactive protein
Alcohol consumption and plasma concentration of C-reactive protein
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DOI：
10.1161/01.cir.0000045669.16499.ec
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发表时间：
2003-01-28
期刊：
影响因子：
37.8
通讯作者：
Ridker, PM
中科院分区：
文献类型：
--
作者：
Albert, MA;Glynn, RJ;Ridker, PM
背景-适量饮酒与较低的心血管死亡率相关。然而，数据评估之间的关系C-反应蛋白（CRP），心血管疾病风险的预测因子，和酒精consumption.Methods和Results-the酒精消费量和CRP之间的关系进行了评估，在一个横断面调查，随着时间的推移，1732名男性和1101名女性参与普伐他汀炎症/CRP评价研究。中度饮酒者的CRP水平低于轻度或偶尔饮酒者：5种酒精摄入量（不饮酒或每日饮酒≥ 2次），中位CRP水平为2.60 mg/L（四分位距（IQR），1.20至5.30 mg/L），2.20 mg/L（IQR，1.00至4.40 mg/L）、1.70 mg/L（IQR，0.80至3.80 mg/L）、1.60 mg/L（IQR，0.80至3.30 mg/L）和1.80 mg/L（IQR，0.80至2.90 mg/L）。这种关系存在于男性、未接受激素替代疗法的女性、不吸烟者以及有和无心血管疾病史的个体中（均P
Background-Moderate alcohol intake has been associated with lower cardiovascular mortality. However, data evaluating the relationship between C-reactive protein (CRP), a predictor of cardiovascular risk, and alcohol consumption are sparse.Methods and Results-The relationship between alcohol consumption and CRP was evaluated in a cross-sectional survey and over time among 1732 men and 1101 women participating in the Pravastatin Inflammation/CRP Evaluation Study. CRP levels were lower in those with moderate alcohol intake versus light or occasional intake: in 5 categories of alcohol intake (no alcohol or = 2 drinks daily), median CRP levels were 2.60 mg/L (interquartile range (IQR), 1.20 to 5.30 mg/L), 2.20 mg/L (IQR, 1.00 to 4.40 mg/L), 1.70 mg/L (IQR, 0.80 to 3.80 mg/L), 1.60 mg/L (IQR, 0.80 to 3.30 mg/L), and 1.80 mg/L (IQR, 0.80 to 2.90 mg/L), respectively. This relationship was present among men, women not taking hormone replacement therapy, nonsmokers, and those individuals with and without a history of cardiovascular disease (all P