Pigs as source of methicillin-resistant Staphylococcus aureus CC398 infections in humans, Denmark.
Pigs as source of methicillin-resistant Staphylococcus aureus CC398 infections in humans, Denmark.
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DOI：
10.3201/eid1409.071576
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发表时间：
2008-09
影响因子：
11.8
通讯作者：
Skov RL
中科院分区：
文献类型：
--
作者：
Lewis HC;Mølbak K;Reese C;Aarestrup FM;Selchau M;Sørum M;Skov RL
在农场生活或工作的人，特别是养猪场，感染风险增加。耐甲氧西林金黄色葡萄球菌(MRSA)的一个新亚型，克隆复合体(CC)398，与动物，特别是猪有关。我们进行了配对的病例对照和病例-病例研究，比较了21例CC398病例和从丹麦民事登记处随机选择的2名对照和2名感染非CC398的MRSA的病例-患者。在病例患者的农场，对动物进行MRSA检查。13例患者报告了猪接触。在病例对照(匹配优势比[MOR]35.4，95%可信区间[CI]2.7-469.8)和病例-病例研究(MOR14.5，95%CI2.7-76.7)中，与动物一起生活或在农场工作是CC398的独立危险因素。仅在病例对照研究中，住院史与风险增加相关(MOR11.4，95%可信区间1.4-94.8)。在5个养殖场中，4个养殖场的50头猪中有23头CC398阳性。我们的结果得到了微生物测试的证实，证明猪是丹麦CC398的来源。
Persons living or working on farms, particularly pig farms, are at increased risk for infection. An emerging subtype of methicillin-resistant Staphylococcus aureus (MRSA), clonal complex (CC) 398, is associated with animals, particularly pigs. We conducted a matched case–control and a case–case study comparing 21 CC398 case-patients with 2 controls randomly selected from the Danish Civil Registry and 2 case-patients infected with MRSA other than CC398. On farms of case-patients, animals were examined for MRSA. Thirteen case-patients reported pig exposure. Living or working on farms with animals was an independent risk factor for CC398 in the case–control (matched odds ratio [MOR] 35.4, 95% confidence interval [CI] 2.7–469.8) and the case–case study (MOR 14.5, 95%CI 2.7–76.7). History of hospitalization was associated with an increased risk only in the case–control study (MOR 11.4, 95% CI 1.4–94.8). A total of 23 of 50 pigs on 4 of 5 farms were positive for CC398. Our results, corroborated by microbiologic testing, demonstrate that pigs are a source of CC398 in Denmark.