Severe pulmonary hypertension without right ventricular failure: The unique hearts of patients with Eisenmenger syndrome
Severe pulmonary hypertension without right ventricular failure: The unique hearts of patients with Eisenmenger syndrome
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DOI：
10.1016/s0002-9149(01)02159-2
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发表时间：
2002-01-01
影响因子：
2.8
通讯作者：
Waggoner, AD
中科院分区：
文献类型：
--
作者：
Hopkins, WE;Waggoner, AD
为什么患有艾森曼格综合征的成年人比其他患有严重肺动脉高压的患者好得多尚不清楚，但可能与仅在这些患者和正常胎儿中发现的独特血液动力学有关。我们用超声心动图评价80例患者的心室形态和功能：45例患有艾森曼格综合征的青紫成人和5例患有艾森曼格综合征的青紫青少年，10例患有非限制性室间隔缺损和左向右分流（艾森曼格期前）的婴儿，以及20例心脏结构正常的胎儿。4组心脏横切面形态相同，整个心动周期室间隔平坦，左右心室自由壁厚度相等(回归斜率0.98,r = 0.97, p
Why adults with the Eisenmenger syndrome fare so much better than other patients with severe pulmonary hypertension is not known, but may be related to unique hemodynamics found only in these patients and in normal fetuses. We used echocardiography to evaluate ventricular morphology and function in 80 subjects: 45 cyanotic adults and 5 cyanotic adolescents with Eisenmenger syndrome, 10 infants with nonrestrictive ventricular septal defect and left-to-right shunt flow (pre-Eisenmenger phase), and 20 fetuses with structurally normal hearts. Cross-sectional morphology of the hearts was the same in all 4 groups with a flat ventricular septum throughout the cardiac cycle and equal thickness of the right and left ventricular free walls (regression slope 0.98, r = 0.97, p