Clinical characteristics of fatalities due to influenza A (H1N1) virus in Mexico
Clinical characteristics of fatalities due to influenza A (H1N1) virus in Mexico
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DOI：
10.1136/thx.2009.126953
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发表时间：
2010-06-01
期刊：
影响因子：
10
通讯作者：
Diaz-Olavarrieta, Claudia
中科院分区：
文献类型：
--
作者：
Fajardo-Dolci, German;Gutierrez-Vega, Rafael;Diaz-Olavarrieta, Claudia
背景由于甲型HIN1流感大流行，墨西哥经历了不成比例的死亡负担。方法对2009年4月10日至5月28日联邦卫生部报告的首批100例甲型H1N1流感确诊死亡病例进行临床分析。统计分析包括患病频率和与国家健康数据的描述性比较。结果大多数患者(60%)年龄在30-79岁，53%为女性，40%为墨西哥城居民。入院时，50%的人有一种或多种慢性疾病，包括代谢综合征(40%)、心血管疾病(21%)、糖尿病(20%)、高血压(20%)和呼吸系统疾病(8%)。根据体重指数，38%的女性和26%的男性肥胖)。主要临床症状为发热(84%)、咳嗽(85%)、呼吸困难(75%)和肌痛(30%)。该样本中所有慢性病的发病率均高于国家统计数据。大多数人(82%)在墨西哥政府发布流感警报之前(4月24日)出现症状。死亡前平均住院天数为4天(0-58天)。结论死于甲型HIN1流感的患者入院时罹患一种或多种慢性病的频率较高。大多数人在卫生当局启动国家流感控制措施后不久死亡。
Background Mexico has experienced a disproportionate mortality burden due to the influenza A(HIN1) pandemic. A study was undertaken to investigate the sociodemographic and clinical characteristics of the first 100 patients who died from confirmed influenza A(H1N1).Methods A clinical evaluation was made of the first 100 consecutive deaths of confirmed cases between 10 April and 28 May 2009 reported by the Federal Ministry of Health. Statistical analysis included disease frequencies and descriptive comparisons with national health data.Results Most patients (60%) were aged 30-79 years, 53% were female and 40% were residents of Mexico City. On admission, 50% had one or more chronic medical conditions including metabolic syndrome (40%), cardiovascular disease (21%), diabetes (20%), hypertension (20%) and respiratory disease (8%). 38% of women and 26% of men were obese based on body mass index). The main clinical symptoms were fever (84%), cough (85%), dyspnoea (75%) and myalgia (30%). The frequency of all chronic diseases was higher in this sample than in the national statistics. Most (82%) developed symptoms before the Mexican government issued the influenza alert (24 April). Median hospital stay prior to death was 4 days (range 0-58).Conclusions Patients, mostly young adults, who died from A(HIN1) influenza had a high frequency of one or more chronic diseases upon admission. Most died shortly after the health authorities initiated national influenza control measures.