Far-red BODIPY-based oxime esters: photo-uncaging and drug delivery.
Far-red BODIPY-based oxime esters: photo-uncaging and drug delivery.
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DOI：
10.1039/d3tb01867a
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发表时间：
2023-10
期刊：
影响因子：
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通讯作者：
Zhaoxiong Wan;Shupei Yu;Qi Wang;Karthik Sambath;Roshena Harty;Xiangshan Liu;Hao Chen;Chen Wang;Xuan Liu;Yuanwei Zhang
中科院分区：
文献类型：
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作者：
Zhaoxiong Wan;Shupei Yu;Qi Wang;Karthik Sambath;Roshena Harty;Xiangshan Liu;Hao Chen;Chen Wang;Xuan Liu;Yuanwei Zhang
设计用于光解锁的基于远红BODIPY的肟酯以与羧酸一起释放感兴趣的分子。低功率红色LED灯断开N-O肟酯键并释放笼状分子。我们使用1H NMR光谱仪研究了释放过程的机理和动力学。此外，在体外使用这种远红BODIPY光撑开策略来测试按需释放丙戊酸（VPA）的药物递送策略以诱导肿瘤细胞的凋亡。
Far-red BODIPY-based oxime esters for photo-uncaging were designed to release molecules of interest with carboxylic acids. The low power red LED light breaks the N-O oxime ester bond and frees the caged molecules. We studied the mechanism and kinetics of the uncaging procedure using a 1H NMR spectrometer. Moreover, the drug delivery strategy to release valproic acid (VPA) on demand was tested in vitro using this far-red BODIPY photo-uncaging strategy to induce apoptosis in tumor cells.