NEW STRATEGIES FOR COMBATING SEPSIS - THE MAGIC BULLETS MISSED THE MARK...BUT THE SEARCH CONTINUES
NEW STRATEGIES FOR COMBATING SEPSIS - THE MAGIC BULLETS MISSED THE MARK...BUT THE SEARCH CONTINUES
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DOI：
10.1016/s0167-7799(00)88906-4
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发表时间：
1995-02-01
影响因子：
17.3
通讯作者：
NATANSON, C
中科院分区：
文献类型：
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作者：
QUEZADO, ZMN;BANKS, SM;NATANSON, C
尽管科学家和业界抱有很高的期望，但针对脓毒症的抗内毒素和抗细胞因子疗法的多项临床试验未能证明其疗效。事实上，在某些情况下，所使用的药物实际上对患者有害。回想起来，也许这些疗法所依据的治疗前提是有缺陷的。未来，对脓毒症的更好理解应该会导致准确的实验室和临床预测指标的开发，这些预测指标将确定患者何时以及哪些患者可以从特定的治疗中受益。我们从工业界和学术界的努力中学到了很多东西，希望能够继续寻找这种致命综合症的新疗法。
Despite the high expectations of scientists and industry, multiple clinical trials of anti-endotoxin- and anti-cytokine-based therapies for sepsis have failed to demonstrate benefit. Indeed, in some cases, the agents used were actually harmful to patients. In retrospect, perhaps the therapeutic premises on which these therapies were based were flawed. In the future, a better understanding of sepsis should lead to the development of accurate laboratory and clinical predictors that will identify when, and which, patients can benefit from a given therapy. Much has been learned from the efforts of industry and academia and, hopefully, the search for new therapies for this lethal syndrome will continue.