An emerging role for the lipid mediator sphingosine-1-phosphate in mast cell effector function and allergic disease.
An emerging role for the lipid mediator sphingosine-1-phosphate in mast cell effector function and allergic disease.
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脂质介质鞘氨醇1-磷酸在肥大细胞效应子功能和过敏性疾病中的新兴作用。
DOI：
10.1007/978-1-4419-9533-9_8
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发表时间：
2011
影响因子：
--
通讯作者：
Rivera, Juan
中科院分区：
文献类型：
--
作者：
Olivera, Ana;Rivera, Juan
鞘氨醇-1-磷酸（S1 P）在调节包括免疫系统在内的多种生物系统的功能中起着重要作用。S1 P主要通过其在细胞膜上的受体作用来影响免疫细胞功能，但它也可以在产生它的细胞中诱导S1 P受体非依赖性反应。过敏性刺激的肥大细胞中产生的S1 P通过S1 P受体依赖性和非依赖性机制介导脱粒、细胞因子和脂质介质的产生以及肥大细胞向抗原的迁移。即使在没有抗原攻击的情况下，肥大细胞的分化和反应性也会受到来自非肥大细胞来源的升高的S1 P的长期暴露的影响，这可能发生在病理生理条件下，可能导致肥大细胞的高反应性。S1 P的作用超出了肥大细胞功能的调节，扩展到周围或远端环境的调节。S1 P从抗原刺激的肥大细胞中输出并进入细胞外空间，并且组织内产生的S1 P梯度可能影响不同的周围组织细胞和过敏性疾病的几个方面，例如炎症或组织重塑。此外，最近的研究结果表明，由肥大细胞全身释放的血管活性介质诱导非造血隔室中S1 P的产生，在那里它在调节血管张力和减少过敏性休克的低血压特征中起作用，从而帮助恢复。S1 P的双重作用，促进肥大细胞的即时反应，同时控制肥大细胞活性的系统后果将被详细讨论。
Sphingosine-1-phosphate (S1P) plays important roles regulating functions of diverse biological systems, including the immune system. S1P affects immune cell function mostly by acting through its receptors at the cell membrane but it can also induce S1P receptor-independent responses in the cells where it is generated. S1P produced in allergically stimulated mast cells mediates degranulation, cytokine and lipid mediator production, and migration of mast cells towards antigen by mechanisms that are both S1P receptor-dependent and independent. Even in the absence of an antigen challenge, the differentiation and responsiveness of mast cells can be affected by chronic exposure to elevated S1P from a non-mast cell source, which may occur under pathophysiological conditions, potentially leading to the hyper-responsiveness of mast cells. The role of S1P extends beyond the regulation of the function of mast cells to the regulation of the surrounding or distal environment. S1P is exported out of antigen-stimulated mast cells and into the extracellular space and the resulting S1P gradient within the tissue may influence diverse surrounding tissue cells and several aspects of the allergic disease, such as inflammation or tissue remodeling. Furthermore, recent findings indicate that vasoactive mediators released systemically by mast cells induce the production of S1P in non-hematopoietic compartments, where it plays a role in regulating the vascular tone and reducing the hypotension characteristic of the anaphylactic shock and thus helping the recovery. The dual actions of S1P, promoting the immediate response of mast cells, while controlling the systemic consequences of mast cell activity will be discussed in detail.
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DOI：
10.1126/science.1176709
发表时间：
2009-09-04
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Hait NC;Allegood J;Maceyka M;Strub GM;Harikumar KB;Singh SK;Luo C;Marmorstein R;Kordula T;Milstien S;Spiegel S
通讯作者：
Spiegel S
影响因子：
4.8
作者：
Haenel, Petra;Andreani, Paul;Graeler, Markus H.
通讯作者：
Graeler, Markus H.
影响因子：
4.8
作者：
Boujaoude, LC;Bradshaw-Wilder, C;Obeid, LM
通讯作者：
Obeid, LM
影响因子：
4.4
作者：
Czeloth, Niklas;Schippers, Angela;Foerster, Reinhold
通讯作者：
Foerster, Reinhold
影响因子：
8.8
作者：
Budde, K;Schmouder, RL;Neumayer, HH
通讯作者：
Neumayer, HH