The Ubiquitination of NF-κB Subunits in the Control of Transcription.
The Ubiquitination of NF-κB Subunits in the Control of Transcription.
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DOI：
10.3390/cells5020023
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发表时间：
2016-05-12
期刊：
影响因子：
6
通讯作者：
Carmody RJ
中科院分区：
文献类型：
--
作者：
Collins PE;Mitxitorena I;Carmody RJ
核因子 (NF)-κB 已进化为潜在的诱导型转录因子家族，对于控制炎症反应至关重要。涉及炎症和免疫稳态的数百个基因的转录需要 NF-κB，因此需要对其进行严格控制。 κB (IκB) 细胞质抑制剂蛋白的诱导性泛素化和蛋白酶体降解可促进 NF-κB 的核转位和转录活性。最近，泛素化在 NF-κB 活性调节中的另一个作用已被确定。在这种情况下，NF-κB 亚基本身的泛素化和降解在 NF-κB 活性的终止和相关转录反应中起着关键作用。虽然还有很多东西有待发现，但现已鉴定出许多 NF-κB 泛素连接酶和去泛素酶，它们可以协调调节 NF-κB 转录反应。本综述将重点关注泛素化对 NF-κB 亚基的调节、关键调节成分及其对 NF-κB 定向转录的影响。
Nuclear factor (NF)-κB has evolved as a latent, inducible family of transcription factors fundamental in the control of the inflammatory response. The transcription of hundreds of genes involved in inflammation and immune homeostasis require NF-κB, necessitating the need for its strict control. The inducible ubiquitination and proteasomal degradation of the cytoplasmic inhibitor of κB (IκB) proteins promotes the nuclear translocation and transcriptional activity of NF-κB. More recently, an additional role for ubiquitination in the regulation of NF-κB activity has been identified. In this case, the ubiquitination and degradation of the NF-κB subunits themselves plays a critical role in the termination of NF-κB activity and the associated transcriptional response. While there is still much to discover, a number of NF-κB ubiquitin ligases and deubiquitinases have now been identified which coordinate to regulate the NF-κB transcriptional response. This review will focus the regulation of NF-κB subunits by ubiquitination, the key regulatory components and their impact on NF-κB directed transcription.