Repeated bereavement, depressed mood, and immune parameters in HIV seropositive and seronegative gay men.
Repeated bereavement, depressed mood, and immune parameters in HIV seropositive and seronegative gay men.
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HIV 血清阳性和血清阴性男同性恋者的反复丧亲之痛、抑郁情绪和免疫参数。
DOI：
10.1037//0278-6133.13.1.14
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Fahey,JL
中科院分区：
文献类型：
--
作者：
Kemeny,ME;Weiner,H;Taylor,SE;Schneider,S;Visscher,B;Fahey,JL
在人类免疫缺陷病毒（HIV）血清阳性的男同性恋者和HIV血清阴性的男同性恋者的样本中，确定了丧亲之痛、抑郁情绪和免疫学模式对获得性免疫缺陷综合征（AIDS）发展的预后之间的关系。在45名最近经历过亲密朋友死亡的男性和45名匹配的非丧亲男性中评估了免疫参数。没有发现有丧亲之痛和没有丧亲之痛的男性之间的免疫差异。在HIV血清阳性的非丧偶男性中，较高的抑郁情绪与较少的CD 4（辅助/诱导）T淋巴细胞，更多的活化CD 8（抑制/细胞毒性）T细胞，和较低的增殖反应有丝分裂原植物血凝素。总之，HIV血清阳性的男性，谁报告了较高水平的抑郁情绪与丧亲表现出免疫模式与HIV活动和进展一致。
The relationships among bereavement, depressed mood, and immunologic patterns prognostic for the development of acquired immunodeficiency syndrome (AIDS) were determined in a sample of human immunodeficiency virus (HIV) seropositive gay men and a comparison group of HIV seronegative gay men. Immunologic parameters were assessed in 45 men who had recently experienced the deaths of close friends and 45 matched nonbereaved men. No immune differences were found between bereaved and nonbereaved men. Among the HIV seropositive nonbereaved men, higher depressed mood was significantly associated with fewer CD4 (helper/inducer) T lymphocytes, more activated CD8 (suppressor/cytotoxic) T cells, and lower proliferative responses to the mitogen phytohemagglutinin. In summary, HIV seropositive men who reported higher levels of depressed mood not associated with bereavement demonstrated immunologic patterns consistent with HIV activity and progression.