Assessment of cognitive, psychiatric, and behavioral disturbances in patients with dementia: the Neurobehavioral Rating Scale.
Assessment of cognitive, psychiatric, and behavioral disturbances in patients with dementia: the Neurobehavioral Rating Scale.
复制标题
痴呆患者认知、精神和行为障碍的评估：神经行为评定量表。
DOI：
10.1111/j.1532-5415.1992.tb02101.x
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发表时间：
1992
影响因子：
6.3
通讯作者：
Cummings,JL
中科院分区：
文献类型：
--
作者：
Sultzer,DL;Levin,HS;Mahler,ME;High,WM;Cummings,JL
目的评估神经行为评定量表（NRS）在阿尔茨海默病（AD）或多梗死性痴呆（MID）患者中的有效性，并描述这些患者发生的认知、精神和行为障碍。DesignCross分段评价。西洛杉矶VAMC老年精神病学住院部、神经行为住院部和痴呆诊所；加州大学洛杉矶分校阿尔茨海默病诊所。患者：61例AD患者和22例mid患者的方便样本。主要结果测量NRS，一个27项观察者评分的工具，测量认知、精神和行为障碍。结果NRS在本组患者中具有较好的内容性和收敛效度。NRS评分的主成分分析确定了六个因素的解决方案，每个因素包含临床相关症状。影响因素为认知/洞察力、躁动/去抑制、行为迟缓、焦虑/抑郁、言语输出障碍和精神病。在AD患者中，躁动、去抑制、敌意、洞察力差、动机差、多疑和妄想在痴呆晚期患者中更为严重。轻度和晚期痴呆患者出现抑郁症状的严重程度相同，但AD发病年龄越早的患者抑郁情绪越严重。结论NRS是一种有用的工具，可以对痴呆患者的认知、精神和行为障碍进行结构化评估。
ObjectiveTo assess the validity of the Neurobehavioral Rating Scale (NRS) in patients with Alzheimer's disease (AD) or multi‐infarct dementia (MID) and to characterize the cognitive, psychiatric, and behavioral disturbances that occur in these patients.DesignCross‐sectional evaluation.SettingWest Los Angeles VAMC Geropsychiatry Inpatient Unit, Neurobehavior Inpatient Unit, and Dementia Clinic; UCLA Alzheimer's Disease Clinic.PatientsConvenience sample of 61 patients with AD and 22 patients with MID.Main Outcome MeasureThe NRS, a 27‐item observer‐rated instrument that measures cognitive, psychiatric, and behavioral disturbances.ResultsThe NRS demonstrated content and convergent validity in this patient group. Principal components analysis of the NRS ratings identified a six‐factor solution, and each factor contained clinically related symptoms. The factors were Cognition/Insight, Agitation/Disinhibition, Behavioral Retardation, Anxiety/Depression, Verbal Output Disturbance, and Psychosis. Among the patients with AD, agitation, disinhibition, hostility, poor insight, poor motivation, suspiciousness, and delusions were more severe in patients with more advanced dementia. Depressive symptoms occurred with equal severity in patients with mild and advanced dementia, but depressed mood was more severe in patients with earlier age of onset of AD.ConclusionThe NRS is a useful instrument for structured assessment of a broad range of cognitive, psychiatric, and behavioral disturbances in patients with dementia.