MYOCYTE CELL LOSS AND MYOCYTE HYPERTROPHY IN THE AGING RAT-HEART
MYOCYTE CELL LOSS AND MYOCYTE HYPERTROPHY IN THE AGING RAT-HEART
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DOI：
10.1016/s0735-1097(86)80321-7
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发表时间：
1986-12-01
影响因子：
24
通讯作者：
OLIVETTI, G
中科院分区：
文献类型：
--
作者：
ANVERSA, P;HILER, B;OLIVETTI, G
为了确定年龄对心肌的影响，研究了 3、10 至 12 和 19 至 21 个月龄大鼠心脏的功能和结构特征。三组动物的体循环动脉压、左心室压及其一阶导数（dP/dt）和心率具有可比性。在 3 个月和 10 至 12 个月之间，左心室和右心室的平均每个核肌细胞体积分别增加了 53% 和 26%。任一心室中肌细胞核的总数保持恒定。在接下来的 10 至 12 个月和 19 至 21 个月期间，发现左侧心脏的细胞进一步肥大 39%，同时心室细胞损失 18%。细胞损失伴随着心内膜下离散的间质和替代纤维化区域。相比之下，右心室没有观察到心肌损伤，并且测量到的心肌细胞额外增大了 35%，而细胞数量没有变化。因此，衰老的左心室由较少数量的肥大细胞组成。细胞肥大可以解释老化心肌的心脏功能未发生改变。
To determine the effects of age on the myocardium, the functional and structural characteristics of the heart were studied in rats at 3, 10 to 12 and 19 to 21 months of age. Systemic arterial pressure, left ventricular pressure and its first derivative (dP/dt) and heart rate were comparable in the three animal groups. In the interval between 3 and 10 to 12 months, mean myocyte cell volume per nucleus increased 53 and 26% in the left and the right ventricle, respectively. The total number of myocyte nuclei remained constant in either ventricle. In the following period, between 10 to 12 and 19 to 21 months, a 39% further cellular hypertrophy on the left side of the heart was found in association with an 18% loss of cells in the ventricle. Cell loss was accompanied by discrete areas of interstitial and replacement fibrosis in the subendocardium. In contrast, no myocardial damage was observed in the right ventricle, and the measured 35% additional enlargement of myocytes occurred without a change in cell number. Thus, the aging left ventricle is composed of a smaller number of hypertrophied cells. Cellular hypertrophy may explain the unaltered cardiac function of the aged myocardium.