Diffusion tensor imaging with tract-based spatial statistics reveals local white matter abnormalities in preterm infants
Diffusion tensor imaging with tract-based spatial statistics reveals local white matter abnormalities in preterm infants
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DOI：
10.1016/j.neuroimage.2007.01.035
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发表时间：
2007-04-15
期刊：
影响因子：
5.7
通讯作者：
Counsell, Serena J.
中科院分区：
文献类型：
--
作者：
Anjari, Mustafa;Srinivasan, Latha;Counsell, Serena J.
早产儿在儿童后期具有高发生率的神经发育损伤，通常与不明确的脑白色物质异常有关。扩散张量成像量化了组织内水的扩散，并可以评估发育中的早产儿大脑的微观结构异常。基于区域的空间统计（TBSS）是一种自动化的非依赖性方法，用于对齐来自多个受试者的分数各向异性（FA）图像，以允许对扩散张量成像数据进行分组比较。我们应用TBSS来检验以下假设：与足月出生的对照组相比，早产儿白色物质特定区域的各向异性分数降低。我们研究了26名在常规磁共振成像（MRI）上无局灶性病变证据的早产儿（足月相当年龄）和6名健康足月出生的对照婴儿。我们发现早产儿的半卵圆中心、额部白色物质和胼胝体胚的FA值显著降低。胎龄小于或等于28周出生的婴儿（n=11）显示外囊、内囊后肢后部以及胼胝体峡部和中部FA额外减少。这项研究表明，TBSS提供了一种不依赖于胎儿的方法，在没有局灶性病变的情况下，在足月相当的年龄识别早产儿脑中的白色异常。(C)2007年爱思唯尔公司All rights reserved.
infants born preterm have a high incidence of neurodevelopmental impairment in later childhood, often associated with poorly defined cerebral white matter abnormalities. Diffusion tensor imaging quantifies the diffusion of water within tissues and can assess microstructural abnormalities in the developing preterm brain. Tract-based spatial statistics (TBSS) is an automated observer-independent method of aligning fractional anisotropy (FA) images from multiple subjects to allow groupwise comparisons of diffusion tensor imaging data. We applied TBSS to test the hypothesis that preterm infants have reduced fractional anisotropy in specific regions of white matter compared to term-born controls. We studied 26 preterm infants with no evidence of focal lesions on conventional magnetic resonance imaging (MRI) at term equivalent age and 6 healthy term-born control infants. We found that the centrum semiovale, frontal white matter and the germ of the corpus callosum showed significantly lower FA in the preterm group. Infants born at less than or equal to 28 weeks gestational age (n=11) displayed additional reductions in FA in the external capsule, the posterior aspect of the posterior limb of the internal capsule and the isthmus and middle portion of the body of the corpus callosum. This study demonstrates that TBSS provides an observer-independent method of identifying white matter abnormalities in the preterm brain at term equivalent age in the absence of focal lesions. (C) 2007 Elsevier Inc. All rights reserved.