Flavonoids Isolated from Heat-Processed Epimedium koreanum and Their Anti-HIV-1 Activities
Flavonoids Isolated from Heat-Processed Epimedium koreanum and Their Anti-HIV-1 Activities
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热处理朝鲜淫羊藿中分离的黄酮类化合物及其抗 HIV-1 活性
DOI：
10.1002/hlca.201500123
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发表时间：
2015-08-01
影响因子：
1.8
通讯作者：
Lee, Kuo-Hsiung
中科院分区：
文献类型：
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作者：
Li, Hong-Mei;Zhou, Cheng;Lee, Kuo-Hsiung
对朝鲜淫羊藿（Epimedium koreanum）的热处理工艺进行了系统的植物化学研究，共分离得到13个黄酮类化合物，其中包括5个新的异戊烯基黄酮醇苷，分别为朝鲜淫羊藿苷（Koreanosides A-E，1-5）。它们的结构被阐明的基础上详细分析的1D-和2D-NMR光谱数据和化学反应。芹菜素（11）具有中等的抗HIV-1活性，EC_（50）为12.8 ± 3.27g/ml。
Systematic phytochemical investigation on heat-processed Epimedium koreanum led to the isolation of 13 flavonoids, including five new prenyl-flavonol glycosides, koreanosides A-E (1-5, resp.). Their structures were elucidated on the basis of detailed analysis of the 1D- and 2D-NMR spectroscopic data and chemical reactions. Apigenin (11) exhibited moderate anti-HIV-1 activity with an EC50 value of 12.8 +/- 3.27g/ml.