The role of oxidative stress in NASH and fatty liver model
The role of oxidative stress in NASH and fatty liver model
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DOI：
10.1016/j.hepres.2005.09.019
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发表时间：
2005-10-01
影响因子：
4.2
通讯作者：
Okita, K
中科院分区：
文献类型：
--
作者：
Sakaida, I;Okita, K
本研究的目的是研究氧化应激是否与肝损伤的发展有关，铁螯合剂去铁胺（13170）可以防止脂质过氧化，从而减轻肝损伤，并减少由胆碱缺乏l -氨基酸定义（CDAA）饮食引起的肿瘤前病变。CDAA饮食组1周后血清ALT水平升高。饲喂CDAA日粮的大鼠肝细胞出现丙二醛（MIDA）积累。但同时给予DFO治疗一周可以降低ALT的升高以及肝脏中MDA的积累。给大鼠喂食CDAA饮食14周，导致严重肝纤维化和肿瘤前病变（酶改变病变）的发展。DFO治疗还可以阻止活化的星状细胞的表达，从而减少肝纤维化，减少肿瘤前病变的发生。这些结果表明，铁螯合可以减少CDAA饮食模型中肿瘤前病变的发展。2005爱思唯尔爱尔兰有限公司版权所有。
The aim of this study was to investigate whether oxidative stress is related to the development of liver injury and an iron chelator, deferoxamine (13170) can prevent lipid peroxidation resulting in reduced liver injury as well as reduce preneoplastic lesions induced by a choline-deficient L-amino acid-defined (CDAA) diet. CDAA diet administration resulted in an increased serum ALT level after one week. Hepatocytes in rat liver fed a CDAA diet showed malondialdehyde (MIDA) accumulation.But simultaneous DFO treatment for one week reduced this elevation of ALT as well as MDA accumulation in the liver. Feeding rats a CDAA diet for 14 weeks led to the development of severe liver fibrosis and preneoplastic lesions detected as enzyme-altered lesions. DFO treatment also prevented the expression of activated stellate cells, resulting in the reduction of liver fibrosis as well as reducing the development of preneoplastic lesions. These results indicate that iron chelation can reduce the development of preneoplastic lesions in a CDAA diet model. (c) 2005 Elsevier Ireland Ltd. All rights reserved.