Dairy products and ovarian cancer: A pooled analysis of 12 cohort studies
Dairy products and ovarian cancer: A pooled analysis of 12 cohort studies
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DOI：
10.1158/1055-9965.epi-05-0484
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发表时间：
2006-02-01
影响因子：
3.8
通讯作者：
Smith-Warner, SA
中科院分区：
文献类型：
--
作者：
Genkinger, JM;Hunter, DJ;Smith-Warner, SA
背景：据推测，乳制品及其成分（乳糖和钙）会促进卵巢癌的发生。尽管病例对照研究报告了乳制品和乳糖的相互矛盾的结果，但一些队列研究表明脱脂牛奶、乳糖和卵巢癌之间存在正相关。方法：对 12 项前瞻性队列研究的主要数据进行了汇总分析。研究人群包括 553,217 名女性，其中确定了 2,132 例上皮性卵巢病例。通过 Cox 比例风险模型计算研究特定的相对风险和 95% 置信区间，然后通过随机效应模型进行汇总。结果：牛奶、奶酪、酸奶、冰淇淋以及膳食和总钙摄入量与卵巢癌风险之间没有观察到统计学上显着的关联。乳糖摄入量 >= 30 与 < 10 g/d 相比，与卵巢癌风险统计学显着升高相关，尽管这种趋势并不具有统计学显着性（汇总多变量相对风险，1.19；95% 置信区间，1.01-1.40；P 趋势 = 0.19）。子宫内膜样癌、粘液性卵巢癌和浆液性卵巢癌的相关性与总体研究结果相似。讨论：总体而言，没有观察到特定乳制品或钙的摄入量与卵巢癌风险之间的相关性。每天摄入三份或更多牛奶的乳糖摄入量会适度增加卵巢癌的风险。由于新的饮食指南建议每天摄入两到三份乳制品，因此在这些消费水平下乳制品摄入量与卵巢癌风险之间的关系值得进一步研究。
Background: Dairy foods and their constituents (lactose and calcium) have been hypothesized to promote ovarian carcinogenesis. Although case-control studies have reported conflicting results for dairy foods and lactose, several cohort studies have shown positive associations between skim milk, lactose, and ovarian cancer.Methods: A pooled analysis of the primary data from 12 prospective cohort studies was conducted. The study population consisted of 553,217 women among whom 2,132 epithelial ovarian cases were identified. Study-specific relative risks and 95% confidence intervals were calculated by Cox proportional hazards models and then pooled by a random-effects model.Results: No statistically significant associations were observed between intakes of milk, cheese, yogurt, ice cream, and dietary and total calcium intake and risk of ovarian cancer. Higher lactose intakes comparing >= 30 versus < 10 g/d were associated with a statistically significant higher risk of ovarian cancer, although the trend was not statistically significant (pooled multivariate relative risk, 1.19; 95% confidence interval, 1.01-1.40; P-trend = 0.19). Associations for endometrioid, mucinous, and serous ovarian cancer were similar to the overall findings.Discussion: Overall, no associations were observed for intakes of specific dairy foods or calcium and ovarian cancer risk. A modest elevation in the risk of ovarian cancer was seen for lactose intake at the level that was equivalent to three or more servings of milk per day. Because a new dietary guideline recommends two to three servings of dairy products per day, the relation between dairy product consumption and ovarian cancer risk at these consumption levels deserves further examination.