R-loops highlight the nucleus in ALS.
R-loops highlight the nucleus in ALS.
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DOI：
10.1080/19491034.2015.1004952
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Mekhail K
中科院分区：
文献类型：
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作者：
Salvi JS;Mekhail K
肌萎缩侧索硬化症（ALS）是一种严重衰弱的神经退行性疾病，与细胞质RNA代谢相关的各种基因突变有关。最近的遗传模型研究也有助于揭示各种ALS相关因子与RNA-DNA杂合（R环）调控之间的联系。在这里，我们研究了这种混合调控过程是如何指向ALS中细胞核的关键作用的。我们还提出了一个潜在的分子机制，其中杂交可能代表至少一个长期寻求不同ALS基因之间的缺失链接。我们的观点是，RNA-DNA杂交体将在破译ALS和其他人类疾病方面发挥关键作用。
Amyotrophic lateral sclerosis (ALS) is a severely debilitating neurodegenerative disease linked to mutations in various genes implicated in cytoplasmic RNA metabolism. Recent studies from genetic models have also helped reveal connections between various ALS-linked factors and RNA-DNA hybrid (R-loop) regulation. Here, we examine how such hybrid-regulatory processes are pointing to a key role for the nucleus in ALS. We also present a potential molecular mechanism in which hybrids may represent at least one of the long sought after missing links between different ALS genes. Our opinion is that RNA-DNA hybrids will play a key role in deciphering ALS and other human diseases.