Genomic structure and transcription of a murine odorant receptor gene: Differential initiation of transcription in the olfactory and testicular cells
Genomic structure and transcription of a murine odorant receptor gene: Differential initiation of transcription in the olfactory and testicular cells
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DOI：
10.1006/bbrc.1996.0580
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发表时间：
1996-04-16
影响因子：
3.1
通讯作者：
Tsuboi, A
中科院分区：
文献类型：
--
作者：
Asai, H;Kasai, H;Tsuboi, A
我们已经表征了小鼠气味受体（OR）基因MOR23的基因组结构和转录。该基因有两个不同的转录起始区，这是差异利用嗅觉和睾丸细胞。我们发现MOR 23基因在编码序列上游的5 '非翻译区内有一个内含子。在嗅觉细胞中，基因的转录起始于该内含子的上游区域，而在睾丸细胞中，转录起始于内含子内。差异启动转录的背景下，组织特异性表达的OR基因进行了讨论。(C)出版社：Academic Press，Inc.
We have characterized genomic structure and transcription of a murine odorant receptor (OR) gene, MOR23. This gene has two distinct transcriptional initiation regions, which are differentially utilized in the olfactory and testicular cells. We have found that the MOR23 gene has an intron within the 5'-untranslated region upstream of the coding sequence. In olfactory cells, transcription of the gene is initiated in the region upstream of this intron, while in testicular cells, transcription starts within the intron. Differential initiation of transcription is discussed in the context of tissue-specific expression of the OR genes. (C) 1996 Academic Press, Inc.