Mild cognitive impairment: Believe it or not?
Mild cognitive impairment: Believe it or not?
复制标题
DOI：
10.1080/09540260802095099
复制
发表时间：
2008-01-01
影响因子：
2.8
通讯作者：
Buschke, Herman
中科院分区：
文献类型：
--
作者：
Allegri, Ricardo F.;Glaser, Frank B.;Buschke, Herman
轻度认知障碍（MCI）以前被定义为痴呆之前的一种过渡状态，但其病情和转化率仍存在争议。 MCI 以及阿尔茨海默病 (AD) 预防现在是自然史研究的焦点。我们审查的目的是考虑 MCI 是否是一个足够成熟的实体，是否可以作为医疗实践中的诊断以及阿尔茨海默病预防治疗的有效目标。 MCI 最初由 Petersen 等人定义。 (1999) 作为进行性记忆丧失、阿尔茨海默病的前驱症状。最近，MCI 已扩展到其他认知领域，并具有其他潜在原因，如正常衰老、额颞叶痴呆和血管性痴呆。尽管召开了许多共识会议，专家们仍无法就 MCI 的关键方面达成一致，特别是在其临床实用性方面。基于神经心理学研究，已提出将 MCI 作为前驱 AD 的海马记忆特征。需要进一步研究来推进这些标准。然而，我们毫不怀疑，未来 AD 作为疾病（不仅仅是痴呆综合征）的诊断将在痴呆前的早期阶段进行，并将结合神经心理学、神经影像学和脑脊液生物标志物进行诊断。
Mild cognitive impairment (MCI) was previously defined as a transitional state that can precede dementia, but the condition and the rates of conversion remain controversial. MCI is now the focus of natural history studies, along with Alzheimer's disease (AD) prevention. The objective of our review will be to consider the question of whether MCI is a well enough established entity that it can be a diagnosis in medical practice and a valid target of Alzheimer's prevention therapy. MCI was originally defined by Petersen et al. (1999) as progressive memory loss, prodrome of Alzheimer's disease. More recently MCI has been expanded to other cognitive domains with other potential causes like normal aging, fronto-temporal dementia, and vascular dementia. Despite many consensus conferences, experts cannot agree on critical aspects of the MCI, particularly with respect to its clinical utility. Based on neuropsychological studies, a hippocampal memory profile has been proposed for MCI as prodromal AD. Further research is needed to advance these criteria. We have no doubt, however, that in the future, the diagnosis of AD as disease (not only a dementia syndrome) will be made in the early pre-dementia stage and will be drawn from a combination of neuropsychological, neuro-imaging and CSF biomarkers.