Incidence of diploid and disomic sperm nuclei in 45 infertile men.
Incidence of diploid and disomic sperm nuclei in 45 infertile men.
复制标题
45 名不育男性的二倍体和二体精子核的发生率。
作者：
M. Guttenbach;M. J. Martínez;H. Michelmann;Wolfgang Engel;M. Schmid
通过单靶点和双靶点原位杂交，研究了 45 名不孕患者的精子细胞的 1、7、10、17、X 和 Y 染色体二体率以及二倍体率。到不孕不育诊所就诊的患者年龄为23-46岁。精液检查显示，患者患有少精子症、少精子症、少精子症、少精子症、少精子症或少精子症。在患者中确定的所有染色体的平均二体率相似，范围从 0.10%（Y 染色体）到 0.14%（10 号和 X 号染色体）。检测到二倍体的平均发生率为 0.1%。除了两名患者的二倍体率显着增加（分别为 0.35% 和 1.6%）外，与健康、可生育的男性相比，不育患者组中的二倍体率和二倍体率均未增加。
Sperm cells from 45 infertile patients were investigated for disomy rates of chromosomes 1, 7, 10, 17, X and Y as well as for diploidy by single- and double-target in-situ hybridization. The patients who attended the infertility clinic were aged 23-46 years. Semenograms showed that the patients had oligo-, astheno-, oligoastheno-, oligoterato-, oligoasthenoterato-, or asthenoteratozoospermia. The average disomy rates determined in the patients were similar for all chromosomes, ranging from 0.10% (chromosome Y) to 0.14% (chromosomes 10 and X). Diploidy was detected with a mean incidence of 0.1%. With the exception of two patients who exhibited significantly increased diploidy rates of 0.35 and 1.6%, neither disomy nor diploidy was increased in the group of infertile patients as compared to healthy, fertile males.