On the Relation between Structure and Biological Function in Transcriptional Networks and ncRNA-Mediated Interactions
On the Relation between Structure and Biological Function in Transcriptional Networks and ncRNA-Mediated Interactions
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发表时间：
2011
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通讯作者：
J. Nacher;N. Araki
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作者：
J. Nacher;N. Araki
我们利用复杂网络方法和优化算法研究了转录网络和非编码RNA介导的相互作用中分子功能的分布。当网络节点属于两个不同的功能类，网络结构的分析，通过两个参数。这些参数定义了一个相图，其边界是使用优化方法计算的。结果表明，分子功能占据网络结构以及在相图中的特定位置。研究结果表明，转录和ncRNA相互作用表现出网络和功能之间的特征耦合，偏离随机预期，支持越来越多的证据表明，在系统水平上的ncRNA调控能力。
We investigate the distribution of molecular functionalities in transcriptional networks and non coding RNA-mediated interactions by using complex network methods and optimization algorithms. When network nodes belong to two distinct functional classes, the networked structure is analyzed by means of two parameters. These parameters define a phase diagram whose boundary is computed using optimization methods. The results reveal that molecular functions occupy specific locations in the networked structure as well as in the phase diagram. The findings show that both transcriptional and ncRNA-interactions exhibit characteristic couplings between network and functionality that deviate from random expectations, supporting growing evidences for a ncRNA regulatory capability at a system level.