Pseudomesotheliomatous carcinoma of the pleura: an autopsy case of metastasis from a G-CSF-producing anaplastic carcinoma of the pancreas.
Pseudomesotheliomatous carcinoma of the pleura: an autopsy case of metastasis from a G-CSF-producing anaplastic carcinoma of the pancreas.
复制标题
胸膜假性间皮瘤癌：产 G-CSF 的胰腺间变性癌转移的尸检病例。
DOI：
10.1111/apm.12789
复制
发表时间：
2018
期刊：
影响因子：
2.8
通讯作者：
Oue N and Yasui W
中科院分区：
文献类型：
--
作者：
Hattori Y;Sentani K;Hattori T;Oue N and Yasui W
假性皮肤瘤癌是一种类似于恶性间皮瘤的沿胸膜延伸的恶性肿瘤。1例81岁男性患者因上腹痛就诊，腹部计算机断层扫描(CT)显示胰尾有一个36毫米的肿瘤。实验室数据显示白细胞计数很高(>；44000/μL)。胸部CT显示左侧胸膜增厚伴胸腔积液。患者对化疗反应差，发病5个月后死于呼吸衰竭。尸检显示胰腺尾部实体瘤有出血，直径6厘米，广泛侵犯胃、左肾上腺、脾和横隔膜。左侧胸膜因受累肿瘤周围增厚，肉眼可见类似胸膜间皮瘤。组织学上，由于缺乏腺体结构或其他提示分化方向的特征，原发胰腺肿瘤被诊断为未分化癌。原发灶和累及左侧胸膜的癌均为G-CSF阳性。我们最近经历了一例产生G-CSF的间变性癌合并假性皮肤瘤扩散的尸检病例。
Pseudomesotheliomatous carcinoma is a malignant tumor that extends along the pleura mimicking malignant mesothelioma. An 81‐year‐old male patient presented to our hospital with epigastralgia, and abdominal computed tomography (CT) showed a 36‐mm tumor in the pancreatic tail. The laboratory data revealed a high leukocyte count (>44 000/μL). Chest CT showed left pleural thickening with pleural effusion. The cancer showed a poor response to chemotherapy, and the patient died of respiratory failure at 5 months after the onset of disease. Autopsy showed solid tumor with hemorrhage, measuring 6 cm in diameter, in the pancreatic tail, with wide invasion to the stomach, left adrenal gland, spleen, and diaphragm. The left pleura, which was circumferentially thickened by the involved tumor, macroscopically resembled pleural mesothelioma. Histologically, the primary pancreatic tumor was diagnosed as anaplastic carcinoma, due to the absence of glandular structures or other features that would indicate a definite direction of differentiation. The primary lesion and carcinoma involving the left pleura were all positive for G‐CSF. We recently experienced an autopsy case of G‐CSF‐producing anaplastic carcinoma with pseudomesotheliomatous spread.