Short-term effects of intensive periodontal therapy on serum inflammatory markers and cholesterol
Short-term effects of intensive periodontal therapy on serum inflammatory markers and cholesterol
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DOI：
10.1177/154405910508400312
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发表时间：
2005-03-01
影响因子：
7.6
通讯作者：
Tonetti, MS
中科院分区：
文献类型：
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作者：
D'Aiuto, F;Nibali, L;Tonetti, MS
严重的牙周炎与全身炎症增加有关。在一项三组初步随机试验中，我们研究了标准（SPT）和强化牙周治疗（IPT）对血清炎症标志物和胆固醇水平的影响。对65例全身健康的重度泛发性牙周炎患者的医疗和牙周参数、C-反应蛋白（CRP）、白细胞介素-6（IL-6）、总胆固醇和低密度脂蛋白胆固醇进行了评价。治疗后两个月，与未治疗的对照组相比，SPT和IPT均导致血清CRP显著降低（SPT为0.5 +/- 0.2 mg/L，P = 0.030; IPT为0.8 +/- 0.2 mg/L，P = 0.001）。对于IL-6观察到类似的结果。炎症的变化与年龄、性别、体重指数和种族无关，但吸烟和治疗方案之间存在显著的相互作用，IPT组在2个月后总胆固醇和LDL胆固醇也有所下降。对这些数据的分析表明，牙周炎在全身健康的受试者中引起中度全身炎症。
Severe periodontitis has been associated with increased systemic inflammation. In a three-arm preliminary randomized trial, we investigated the impact of standard (SPT) and intensive periodontal therapy (IPT) on serum inflammatory markers and cholesterol levels. Medical and periodontal parameters, C-reactive protein (CRP), interleukin-6 (IL-6), total cholesterol, and LDL cholesterol were evaluated in 65 systemically healthy subjects suffering from severe generalized periodontitis. Two months after treatment, both SPT and IPT resulted in significant reductions in serum CRP compared with the untreated control ( 0.5 +/- 0.2 mg/L for SPT, P = 0.030 and 0.8 +/- 0.2 mg/L for IPT, P = 0.001). Similar results were observed for IL-6. Changes in inflammation were independent of age, gender, body mass index, and ethnicity, but a significant interaction between cigarette smoking and treatment regimen was found. The IPT group also showed a decrease in total and LDL cholesterol after 2 months. Analysis of these data indicates that periodontitis causes moderate systemic inflammation in systemically healthy subjects.