The lipoxins. Stereochemical identification and determination of their biosynthesis.
The lipoxins. Stereochemical identification and determination of their biosynthesis.
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DOI：
10.1016/s0021-9258(17)38829-4
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发表时间：
1985-10
期刊：
影响因子：
--
通讯作者：
B. Fitzsimmons;J. Adams;J. Evans;Y. Leblanc;J. Rokach
中科院分区：
文献类型：
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作者：
B. Fitzsimmons;J. Adams;J. Evans;Y. Leblanc;J. Rokach
The stereochemistry and double bond geometry of a novel series of leukocyte-derived arachidonic acid metabolites, the lipoxins, was determined by comparison to pure unambiguous synthetic standards. The lipoxins were found to be a mixture of four lipoxin A isomers and two lipoxin B isomers. In determining the biosynthesis of these compounds, they were shown to be formed via a tetraene epoxide. In addition, it was shown that all of the lipoxin isomers formed by the incubation of 15-hydroperoxyeicosatetraenoic acid with human leukocytes were also formed by nonenzymatic hydrolysis of this tetraene epoxide.
