A dynamic predictive nomogram of long-term survival in primary gastric lymphoma: a retrospective study.
A dynamic predictive nomogram of long-term survival in primary gastric lymphoma: a retrospective study.
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原发性胃淋巴瘤长期生存的动态预测列线图：一项回顾性研究
DOI：
10.1186/s12876-022-02419-2
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发表时间：
2022-07-16
影响因子：
2.4
通讯作者：
Yu, Dandan
中科院分区：
文献类型：
--
作者：
Yang, Jinru;Liu, Tao;Zhu, Ying;Zhang, Fangyuan;Zhai, Menglan;Zhang, Dejun;Zhao, Lei;Jin, Min;Lin, Zhenyu;Zhang, Tao;Zhang, Liling;Yu, Dandan
原发性胃淋巴瘤（PGL）是最常见的结外非霍奇金淋巴瘤（NHL）。由于这种疾病的罕见性，建立一个预测模型，为PGL患者和医生提供治疗和预后是很重要的。从SEER数据库和我们的癌症中心分别获得8898例和127例诊断为PGL的患者作为培训和验证队列。采用单因素和多因素Cox比例风险模型研究独立危险因素，构建预测生存图，并建立网络图，动态预测PGL患者的生存。采用一致性指数（C-index）、校正图和受试者工作特征（ROC）曲线对nomogram模型进行评价和验证。SEER队列中有8898例PGL患者，大多数为60岁以上已婚男性，16.1%的原发肿瘤定位于胃窦和幽门螺杆菌，这与中国队列中127例患者的组成相似，具有可比性。根据诊断年龄、性别、种族、婚姻状况、组织学、分期、放疗和化疗等8个变量编制总生存（OS） Nomogram。癌症特异性生存（CSS） nomogram，包括年龄、性别、婚姻状况、原发肿瘤部位、组织学、分期、放疗和化疗等8个变量。验证组OS预测nomogram C-index为0.948 (95% CI: 0.901 ~ 0.995)，校正图匹配最佳，训练组和验证组的ROC曲线下面积（AUC）均较高。此外，我们建立了第一个基于网络的PGL生存率计算器（https://yangjinru.shinyapps.io/DynNomapp/）。网络动态图为评价OS和CSS患者的PGL预后提供了一个有见地和适用的工具，可以有效地指导个体化治疗和监测。在线版本包含补充材料，可在10.1186/s12876-022-02419-2获得。
Primary gastric lymphoma (PGL) is the most common extranodal non-Hodgkin lymphoma (NHL). Due to the rarity of the disease, it is important to create a predictive model that provides treatment and prognosis for patients with PGL and physicians. A total of 8898 and 127 patients diagnosed with PGL were obtained from the SEER database and from our Cancer Center as training and validation cohorts, respectively. Univariate and multivariate Cox proportional hazards models were used to investigate independent risk factors for the construction of predictive survival nomograms, and a web nomogram was developed for the dynamic prediction of survival of patients with PGL. The concordance index (C-index), calibration plot, and receiver operating characteristics (ROC) curve were used to evaluate and validate the nomogram models. There were 8898 PGL patients in the SEER cohort, most of whom were married men over the age of 60, 16.1% of the primary tumors were localized in the antrum and pylori of the stomach, which was similar to the composition of 127 patients in the Chinese cohort, making both groups comparable. The Nomogram of overall survival (OS) was compiled based on eight variables, including age at diagnosis, sex, race, marital status, histology, stage, radiotherapy and chemotherapy. Cancer-specific survival (CSS) nomogram was developed with eight variables, including age at diagnosis, sex, marital status, primary tumor site, histology, stage, radiotherapy and chemotherapy. The C-index of OS prediction nomogram was 0.948 (95% CI: 0.901–0.995) in the validation cohort, the calibration plots showed an optimal match and a high area below the ROC curve (AUC) was observed in both training and validation sets. Also, we established the first web-based PGL survival rate calculator (https://yangjinru.shinyapps.io/DynNomapp/). The web dynamic nomogram provided an insightful and applicable tool for evaluating PGL prognosis in OS and CSS, and can effectively guide individual treatment and monitoring. The online version contains supplementary material available at 10.1186/s12876-022-02419-2.
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影响因子：
2.4
作者：
Chang, Yu-Tang;Huang, Ming-Yii;Lin, Pei-Chin
通讯作者：
Lin, Pei-Chin
影响因子：
4.1
作者：
Merchionne, Francesca;Iacopino, Pasquale;Guarini, Attilio
通讯作者：
Guarini, Attilio
原发性胃弥漫性大B细胞淋巴瘤的治疗策略和预后因素：中国淋巴瘤患者登记中心272例的回顾性多中心研究
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3.6
作者：
Yang, Haiyan;Wu, Meng;Zhu, Jun
通讯作者：
Zhu, Jun
影响因子：
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作者：
Martini, Alberto;Cumarasamy, Shivaram;Badani, Ketan K.
通讯作者：
Badani, Ketan K.
影响因子：
50.5
作者：
Zucca, E.;Copie-Bergman, C.;Ladetto, M.
通讯作者：
Ladetto, M.