IMPROVEMENT OF BRAIN TISSUE OXYGENATION BY INHALATION OF CARBOGEN
IMPROVEMENT OF BRAIN TISSUE OXYGENATION BY INHALATION OF CARBOGEN
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DOI：
10.1016/j.neuroscience.2008.08.016
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发表时间：
2008-10-28
期刊：
影响因子：
3.3
通讯作者：
Vafaee, M.
中科院分区：
文献类型：
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作者：
Ashkanian, M.;Borghammer, P.;Vafaee, M.
高氧治疗脑缺血可能会减少脑血流量(CBF)，这是因为氧气对脑小动脉的血管收缩作用。我们假设，当吸入的氧气(Carbogen)中添加5%的二氧化碳时，血管扩张占主导地位。为此，我们采用正电子发射断层扫描(PET)技术，测定了10名健康志愿者吸入试验气体(O2、CO2、Carbogen和大气空气)时的脑血流量和脑氧代谢率(CMRO2)。在给药过程中记录动脉血气。使用感兴趣体积和基于体素的统计方法对数据进行分析。吸入二氧化碳或碳氧显著增加全球脑血流量，而纯氧气则降低全球脑血流量。与大气空气吸入条件相比，吸氧期间脑白质中的CMRO2基本保持不变。感兴趣体积的结果通过统计聚类分析得到了证实。氧和碳氧在提高动脉血氧饱和度方面同样有效(SaO(2))。目前的数据表明，吸入Carbogen会增加健康成年人的CBF和SaO(2)。总而言之，我们推测，吸入碳素足以使健康的脑组织获得最佳的氧合，而碳素则会导致CBF和SaO(2)的相应增加。(C)2008年IBRO。爱思唯尔有限公司出版。保留所有权利。
Hyperoxic therapy for cerebral ischemia is suspected to reduce cerebral blood flow (CBF), due to the vasoconstrictive effect of oxygen on cerebral arterioles. We hypothesized that vasodilation predominates when 5% CO2 is added to the inhaled oxygen (carbogen). Therefore, we used positron emission tomography (PET) to measure CBF and cerebral metabolic rate of oxygen (CMRO2) during inhalation of test gases (O-2, CO2, carbogen and atmospheric air) in 10 healthy volunteers. Arterial blood gases were recorded during administration of each gas. The data were analyzed with volume-of-interest and voxel-based statistical methods. Inhalation of CO2 or carbogen significantly increased global CBF, whereas pure oxygen decreased global CBF. The CMRO2 generally remained unchanged, except in white matter during oxygen inhalation relative to condition of atmospheric air inhalation. The volume-of-interest results were confirmed by statistical cluster analysis. Oxygen and carbogen were equally potent in increasing oxygen saturation of arterial blood (SaO(2)). The present data demonstrate that inhalation of carbogen increases both CBF and SaO(2) in healthy adults. In conclusion we speculate that carbogen inhalation is sufficient for optimal oxygenation of healthy brain tissue, whereas carbogen induces concomitant increases of CBF and SaO(2). (C) 2008 IBRO. Published by Elsevier Ltd. All rights reserved.