Synchronous gastric MALT lymphoma and gastric adenocarcinoma of fundic gland type arising from a hamartomatous inverted polyp in a Helicobacter pylori naive patient
Synchronous gastric MALT lymphoma and gastric adenocarcinoma of fundic gland type arising from a hamartomatous inverted polyp in a Helicobacter pylori naive patient
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DOI：
10.1007/s12328-023-01808-8
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发表时间：
2023-04-26
影响因子：
1
通讯作者：
Oka, Shiro
中科院分区：
文献类型：
--
作者：
Miyamoto, Ryo;Takigawa, Hidehiko;Oka, Shiro
我们报告一例罕见的幽门螺杆菌未发病胃中胃癌和粘膜相关淋巴组织淋巴瘤共存的病例。一位72岁的男性在耳鼻喉科接受了声门上皮癌手术后的随访。患者行上消化道内窥镜检查，发现PET-CT异常堆积，显示胃底底腺型胃腺癌，胃上体MALT淋巴瘤。因此，我们对胃癌进行了内镜下粘膜下解剖，并诊断为错构瘤倒置息肉引起的基底腺型胃腺癌。随后，由于API2-MALT1基因阳性，幽门螺杆菌感染阴性，对胃MALT淋巴瘤进行放疗。观察到完全的反应。即使在hp未发作的胃中，像本病例这样的病例也会并发特殊类型的胃癌和MALT淋巴瘤，在进行内镜检查时也应考虑到这些疾病。
We present a rare case that showed the coexistence of gastric cancer and mucosa-associated lymphoid tissue (MALT) lymphoma in Helicobacter pylori-naive stomach. A 72-year-old man was followed up after surgery for epithelial carcinoma of the glottis at the Department of Otolaryngology. He underwent an upper gastrointestinal endoscopy for an abnormal PET-CT accumulation, which revealed gastric adenocarcinoma of fundic gland type in the gastric fundus and MALT lymphoma in the upper gastric body. Hence, we performed an endoscopic submucosal dissection for gastric cancer and diagnosed gastric adenocarcinoma of fundic gland type derived from a hamartomatous-inverted polyp. Subsequently, Gastric MALT lymphoma was treated with radiation therapy because the API2-MALT1 gene was positive and the Helicobacter pylori infection was negative. A complete response was observed. Even in Hp-naive stomachs, cases such as the present case are complicated by special types of gastric cancer and MALT lymphoma, and endoscopic examination should be performed with these diseases in mind.