PEG hydrogel degradation and the role of the surrounding tissue environment.
PEG hydrogel degradation and the role of the surrounding tissue environment.
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DOI：
10.1002/term.1688
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发表时间：
2015-03
影响因子：
3.3
通讯作者：
Elisseeff J
中科院分区：
文献类型：
--
作者：
Reid B;Gibson M;Singh A;Taube J;Furlong C;Murcia M;Elisseeff J
由于易于合成和组织样性质，基于聚乙二醇（PEG）的水凝胶被广泛用于各种生物医学应用。近年来，关于聚乙二醇水凝胶的降解动力学和体内宿主反应的研究报道不一。特别是，这些研究表明，周围组织环境可能在确定PEG植入物的炎症反应和降解动力学方面发挥关键作用。在本研究中，我们证明了PEG水凝胶降解的潜在机制，此外，我们还显示了周围组织环境对产生可变炎症反应的作用的潜在证据。
Poly(ethylene glycol) (PEG)-based hydrogels are extensively used in a variety of biomedical applications due to ease of synthesis and tissue-like properties. Recently, there have been varied reports regarding PEG hydrogel’s degradation kinetics and in vivo host response. In particular, these studies suggest that the surrounding tissue environment could play a critical role in defining the inflammatory response and degradation kinetics of PEG implants. In the present study we demonstrated a potential mechanism of PEG hydrogel degradation, and in addition we show potential evidence of the role of the surrounding tissue environment on producing variable inflammatory responses.