A panel of restriction fragment length polymorphisms for chromosomal band 11p13.
A panel of restriction fragment length polymorphisms for chromosomal band 11p13.
复制标题
染色体带 11p13 的一组限制性片段长度多态性。
DOI：
10.1007/bf00200570
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发表时间：
1990
期刊：
影响因子：
5.3
通讯作者：
Saunders,GF
中科院分区：
文献类型：
--
作者：
Huff,V;Compton,DA;Strong,LC;Saunders,GF
一个面板的7个染色体11 p13限制性片段长度多态性（RFLPs）检测五个DNA探针。两个等位基因被确定为每个多态性，并观察到孟德尔分离的等位基因。等位基因频率范围为0.13/0.87至0.44/0.56。这组11 p13 RFLP将是有用的连锁研究调查的作用，11 p13基因在肾母细胞瘤，无虹膜，泌尿生殖系统异常。此外，这些RFLPs将成为研究Wilms肿瘤和其他癌症中肿瘤特异性11 p13改变的重要工具。
A panel of seven chromosome 11p13 restriction fragment length polymorphisms (RFLPs) detected by five DNA probes is described. Two alleles were identified for each polymorphism, and Mendelian segregation of alleles was observed. Allele frequencies range from 0.13/0.87 to 0.44/0.56. This panel of 11p13 RFLPs will be useful for linkage studies investigating the role of 11p13 genes in Wilms' tumor, aniridia, and genitourinary anomalies. Additionally, these RFLPs will be important tools for studying tumor-specific 11p13 alterations in Wilms' tumor and other cancers.