Multistability: a major means of differentiation and evolution in biological systems
Multistability: a major means of differentiation and evolution in biological systems
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DOI：
10.1016/s0968-0004(99)01473-5
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发表时间：
1999-11-01
影响因子：
13.8
通讯作者：
Kellershohn, N
中科院分区：
文献类型：
--
作者：
Laurent, M;Kellershohn, N
在基因表达或蛋白质功能水平上调节的非常简单的生化系统能够具有复杂的动态行为。在与非线性动力学相关的各种调节模式中，对应于交替稳态之间的真实切换的多稳态允许分级信号沿着沿着几种可能的不同途径转变为系统的不连续进化，它既可以是可逆的，也可以是不可逆的，多稳态在生命的一些基本过程中起着重要的作用。这可能是在没有遗传或环境差异的情况下维持表型差异的原因，正如在大肠杆菌中乳糖操纵子的调节实验所证明的那样。细胞分化也可以解释为多稳定性。
Very simple biochemical systems regulated at the level of gene expression or protein function are capable of complex dynamic behaviour, Among the various patterns of regulation associated with non-linear kinetics, multistability, which corresponds to a true switch between alternate steady states, allows a graded signal to be turned into a discontinuous evolution of the system along several possible distinct pathways, which can be either reversible or irreversible, Multistability plays a significant role in some of the basic processes of life. It might account for maintenance of phenotypic differences in the absence of genetic or environmental differences, as has been demonstrated experimentally for the regulation of the lactose operon in Escherichia coli. Cell differentiation might also be explained as multistability.