Evolutionary theory predicts late-life mortality plateaus
Evolutionary theory predicts late-life mortality plateaus
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DOI：
10.1073/pnas.93.26.15249
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发表时间：
1996-12-24
影响因子：
11.1
通讯作者：
Rose, MR
中科院分区：
文献类型：
--
作者：
Mueller, LD;Rose, MR
大多数人口统计数据表明，随着年龄的增长，成人死亡率大致呈指数增长，这一现象被解释为自然选择对特定年龄死亡率的作用减弱。分散的人口统计学发现表明，人类和双翅目昆虫都存在一个晚年死亡平台，这似乎与先前的数据和进化理论都不一致。对衰老进化理论的扩展表明，当收集到足够的晚年数据时，这种晚年死亡平台是可以预料的。具有拮抗多效性和突变积累两种驱动群体遗传机制。
Most demographic data indicate a roughly exponential increase in adult mortality with age, a phenomenon that has been explained in terms of a decline in the force of natural selection acting on age-specific mortality. Scattered demographic findings suggest the existence of a late-life mortality plateau in both humans and dipteran insects, seemingly at odds with both prior data and evolutionary theory, Extensions to the evolutionary theory of aging are developed which indicate that such late-life mortality plateaus are to be expected when enough late-life data are collected, This expanded theory predicts late-life mortality plateaus, with both antagonistic pleiotropy and mutation accumulation as driving population genetic mechanisms.