Paradoxical Hyperadiponectinemia is Associated With the Metabolically Healthy Obese (MHO) Phenotype in African Americans
Paradoxical Hyperadiponectinemia is Associated With the Metabolically Healthy Obese (MHO) Phenotype in African Americans
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DOI：
10.4021/jem95w
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发表时间：
2012-04-01
影响因子：
0.4
通讯作者：
Rotimi, Charles N.
中科院分区：
文献类型：
--
作者：
Doumatey, Ayo P.;Bentley, Amy R.;Rotimi, Charles N.
背景：已有研究表明，脂联素可能对肥胖带来的不良健康影响提供保护。在这项研究中，我们检测了非裔美国人肥胖人群中反常高脂联素或反常高脂联素血症(PHA)的患病率，并探讨其与代谢性健康肥胖(MHO)表型的关系。方法：对822名来自霍华德大学家族研究(HUFS)的无关参与者进行总脂联素和代谢指标的测定，包括空腹血糖、胰岛素、血脂和肥胖指标。在调整相关协变量的同时，使用Logistic回归模型评估MHO表型与PHA的相关性。结果：总体而言，男性的脂联素水平显著低于女性。然而，在男性和女性中，脂联素水平与肥胖指标、血糖、胰岛素和胰岛素抵抗指数有关。同样比例的肥胖男性和女性受试者(19.2%；66/343)患有PHA；与没有PHA的人相比，这些患有PHA的肥胖者具有更健康的代谢特征，包括更高的高密度脂蛋白-胆固醇、更低的胰岛素水平以及更小的腰围和胰岛素水平。此外，28%(96/343)的研究参与者符合MHO表型标准。有趣的是，在患有PHA的肥胖者中，42%(28/66)也有MHO表型。结论：这些发现证实了非裔美国人中MHO的存在，并证实了PHA与MHO表型的关联。总之，我们的发现以及其他已发表的结果为更系统地研究脂联素保护功能的机制及其在人类代谢疾病中的潜在治疗应用提供了证据。
Background: It has been suggested that adiponectin may offer protection against the adverse health effects of obesity. In this study, we determined the prevalence of paradoxically high adiponectin or paradoxical hyperadiponectinemia (PHA) among obese African Americans and investigated its relationship with the metabolically healthy obese (MHO) phenotype.Methods: Total adiponectin and metabolic markers including fasting glucose, insulin, serum lipids and obesity measures were determined in 822 unrelated participants from the Howard University Family Study (HUFS). Logistic regression models were used to evaluate the association between MHO phenotype and PHA while adjusting for relevant covariates.Results: Overall, men had significantly lower adiponectin levels than women. However, adiponectin level was associated with obesity measures, glucose, insulin and insulin resistance index in both men and women. Equal proportion of the obese male and female subjects (19.2%; 66/343) had PHA; these obese individuals with PHA had a healthier metabolic profile including higher HDL-cholesterol, lower insulin levels and smaller waist circumference and insulin levels compared to those without PHA. Also, 28% (96/343) of the study participants met the criteria of MHO phenotype. Inter-estingly, 42% (28/66) of the obese individuals with PHA also had the MHO phenotype. Finally, the MHO phenotype was associated with PHA in both men and women.Conclusions: These findings confirm the presence of MHO in African Americans and demonstrate the association of PHA with the MHO phenotype. In all, our findings along with other published results provide evidence for a more systematic investigation of the mechanisms underlying the protective function of adiponectin and its potential therapeutic applications in human metabolic disorders.