Shape deformation of the organ of Corti associated with length changes of outer hair cell.
Shape deformation of the organ of Corti associated with length changes of outer hair cell.
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柯蒂氏器的形状变形与外毛细胞长度变化有关。
DOI：
10.3109/00016489609137863
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发表时间：
1996
影响因子：
1.4
通讯作者：
C. Fermin
中科院分区：
文献类型：
--
作者：
U. Zimmermann;C. Fermin
耳蜗外毛细胞（OHC）通常被认为是内耳Corti器官（OC）中的机械效应器和感觉受体。体外和器官外植体中的OHC表现出对电、化学或机械刺激的机械响应，这可能代表了体内预期的效应器过程的一个方面。一个详细的描述，但是，一个OHC效应器操作原位仍然失踪。具体来说，很少有人知道如何OHC运动影响的OC在原位的几何形状。以前的工作已经证明，孤立的OHC的运动性响应电刺激和K（+）-葡萄糖酸盐可能是在电压控制下，并导致去极化（缩短）和超极化（延长）。这项工作进行调查，如果在孤立的OHC中观察到的运动，这是由离子刺激引起的，可以改变OC的几何形状。将豚鼠耳蜗整个OC暴露于人工内淋巴（K+）中，诱导OHC同步去极化。随后的形态测量显示，从这些耳蜗中蜗轴部分之间的距离基底膜（BM）和网状板（RL）已大大减少。此外，在三个上圈中，所有行的OHC都显着缩短。结果表明，OHC可以改变它们在Corti器官（OC）中的长度，从而使OC的几何形状变形。实验揭示了OC内的紧张力生成，其可以改变RL和/或BM的位置，有助于阻尼，调节BM-RL距离并控制RL和感觉毛束的操作点。因此，结果表明，耳蜗力学的主动自我调整缓慢OHC长度的变化。这种机械调节最近被假定为与动物交流、讲话或音乐的定时元素相对应。
Cochlear outer hair cells (OHC) are commonly assumed to function as mechanical effectors as well as sensory receptors in the organ of Corti (OC) of the inner ear. OHC in vitro and in organ explants exhibit mechanical responses to electrical, chemical or mechanical stimulation which may represent an aspect of their effector process that is expected in vivo. A detailed description, however, of an OHC effector operation in situ is still missing. Specifically, little is known as to how OHC movements influence the geometry of the OC in situ. Previous work has demonstrated that the motility of isolated OHCs in response to electrical stimulation and to K(+)-gluconate is probably under voltage control and causes depolarisation (shortening) and hyperpolarization (elongation). This work was undertaken to investigate if the movements that were observed in isolated OHC, and which are induced by ionic stimulation, could change the geometry of the OC. A synchronized depolarization of OHC was induced in guinea pig cochleae by exposing the entire OC to artificial endolymph (K+). Subsequent morphometry of mid-modiolar sections from these cochleae revealed that the distance between the basilar membrane (BM) and the reticular lamina (RL) had decreased considerably. Furthermore, in the three upper turns OHC had significantly shortened in all rows. The results suggest that OHC can change their length in the organ of Corti (OC) thus deforming the geometry of the OC. The experiments reveal a tonic force generation within the OC that may change the position of RL and/or BM, contribute to damping, modulate the BM-RL-distance and control the operating points of RL and sensory hair bundles. Thus, the results suggest active self-adjustments of cochlear mechanics by slow OHC length changes. Such mechanical adjustments have recently been postulated to correspond to timing elements of animal communication, speech or music.
松鼠猴（Saimiri sciureus）前庭神经的形态测量和超微结构。
DOI：
10.1159/000146398
发表时间：
1987
期刊：
Acta anatomica
影响因子：
--
作者：
Fermin,CD;Igarashi,M
通讯作者：
Igarashi,M