Siderophore mediated iron(III) uptake in Gliocladium virens. 2. Role of ferric mono- and dihydroxamates as iron transport agents.
Siderophore mediated iron(III) uptake in Gliocladium virens. 2. Role of ferric mono- and dihydroxamates as iron transport agents.
复制标题
铁载体介导的 Gliocladium virens 中铁 (III) 的吸收。
DOI：
10.1016/0162-0134(87)80033-8
复制
发表时间：
1987
影响因子：
3.9
通讯作者：
vanderHelm,D
中科院分区：
文献类型：
--
作者：
Jalal,MA;Love,SK;vanderHelm,D
用标记铁铁载体研究了真菌ATCC 24290的主要铁载体--顺式和反式褐腐胺(CF)和二羟氨酸盐(DA)的Fe(III)转运性质。Fe(CF)3、Fe(Tf)3和Fe2(DA)3(也是一种次要的三羟基甲酸酯，铁素)能非常有效地将胞外55Fe(III)输送到真菌中。Coprogen是另一种次要的三羟基甲酸酯，是一种弱的Fe(III)转运剂。呼吸毒物KCN和NaN3显著抑制吸收活性，表明Fe(Cf)3、Fe(Tf)3和Fe2(DA)3介导的Fe(III)吸收涉及膜上活跃的转运系统。许多真菌物种，包括产生和不产生CF、Tf和DA的真菌，都不同程度地表现出运输与这些铁载体结合的55Fe(III)的能力。
The Fe(III) transport properties of the monohydroxamates,cis-fusarinine (cF) andtrans-fusarinine (tF), and the dihydroxamate, dimerum acid (DA), the major siderophores of the fungus,Gliocladium virensATCC 24290, have been investigated using labeled ferric siderophores. Fe(cF)3, Fe(tF)3and Fe2(DA)3(and also one of the minor trihydroxamates, ferricrocin) transport extracellular55Fe(III) very efficiently into the fungus. Coprogen, another minor trihydroxamate, behaves as a weak Fe(III)-transporting agent. The respiratory poisons, KCN and NaN3, significantly inhibit uptake activity, indicating that the Fe(III) uptake mediated by Fe(cF)3, Fe(tF)3, and Fe2(DA)3involves active transport systems in the membrane. A number of fungal species, both producers and nonproducers of cF, tF, and DA, show ability at varying degrees to transport55Fe(III) bound to these siderophores.