Population toxicokinetic modeling of cadmium for health risk assessment.
Population toxicokinetic modeling of cadmium for health risk assessment.
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镉对健康风险评估的毒理动力学建模。
DOI：
10.1289/ehp.0800317
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发表时间：
2009-08
影响因子：
10.4
通讯作者：
Akesson A
中科院分区：
文献类型：
--
作者：
Amzal B;Julin B;Vahter M;Wolk A;Johanson G;Akesson A
镉是一种广泛存在的环境污染物，已被证明在长期接触后会对人类的肾脏和骨骼产生毒性作用。尿镉浓度被认为是肾脏中镉累积的良好生物标志物，饮食是非吸烟者镉的主要来源。建立尿液镉与膳食镉摄入量之间的联系模型是长期镉暴露风险评估的关键步骤。然而，人们对这种联系如何变化知之甚少，尤其是对于易感人群阶层。我们使用了一项基于大规模人群的研究（瑞典乳房 X 线摄影队列），并使用涵盖 20 年时间的重复饮食摄入数据，将估计的膳食镉摄入量与个体尿镉浓度进行比较。根据对尿镉的预测，对 Nordberg-Kjellström 模型的修改版本和单室模型进行了评估。我们整合了模型并量化了人群中镉半衰期的人际差异。最后，进行了敏感性分析和蒙特卡罗模拟，以说明后一个模型如何作为支持人体镉风险评估的强大工具。单室群体模型似乎是将镉摄入量与尿镉联系起来并描述群体变异性的适当建模选择。我们估计镉的半衰期约为 11.6 年，群体变异性约为 25%。群体毒代动力学模型可以成为化学品风险评估的强大且有用的工具，因为它们允许量化和整合毒代动力学中的群体变异性。
Cadmium is a widespread environmental pollutant that has been shown to exert toxic effects on kidney and bones in humans after long-term exposure. Urinary cadmium concentration is considered a good biomarker of accumulated cadmium in kidney, and diet is the main source of cadmium among nonsmokers. Modeling the link between urinary cadmium and dietary cadmium intake is a key step in the risk assessment of long-term cadmium exposure. There is, however, little knowledge on how this link may vary, especially for susceptible population strata. We used a large population-based study (the Swedish Mammography Cohort), with repeated dietary intake data covering a period of 20 years, to compare estimated dietary cadmium intake with urinary cadmium concentrations on an individual basis. A modified version of the Nordberg-Kjellström model and a one-compartment model were evaluated in terms of their predictions of urinary cadmium. We integrated the models and quantified the between-person variability of cadmium half-life in the population. Finally, sensitivity analyses and Monte Carlo simulations were performed to illustrate how the latter model could serve as a robust tool supporting the risk assessment of cadmium in humans. The one-compartment population model appeared to be an adequate modeling option to link cadmium intake to urinary cadmium and to describe the population variability. We estimated the cadmium half-life to be about 11.6 years, with about 25% population variability. Population toxicokinetic models can be robust and useful tools for risk assessment of chemicals, because they allow quantification and integration of population variability in toxicokinetics.
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DOI：
10.1038/sj.jes.7500554
发表时间：
2007-09-01
影响因子：
4.5
作者：
Egan, Sara Kathleen;Bolger, Philip Michael;Carrington, Clark Dewitt
通讯作者：
Carrington, Clark Dewitt
影响因子：
10.4
作者：
Nawrot TS;Van Hecke E;Thijs L;Richart T;Kuznetsova T;Jin Y;Vangronsveld J;Roels HA;Staessen JA
通讯作者：
Staessen JA
DOI：
10.1080/15287390306384
发表时间：
2003-05-09
影响因子：
2.6
作者：
de Burbure, C;Buchet, JP;Mutti, A
通讯作者：
Mutti, A
影响因子：
51.1
作者：
Nawrot, T;Plusquin, M;Staessen, JA
通讯作者：
Staessen, JA
DOI：
10.1080/15287390390227589
发表时间：
2003-11-28
期刊：
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A
影响因子：
--
作者：
Diamond, GL;Thayer, WC;Choudhury, H
通讯作者：
Choudhury, H