Association of CRP levels with ARMS2 and CFH variants in age-related macular degeneration
Association of CRP levels with ARMS2 and CFH variants in age-related macular degeneration
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DOI：
10.1007/s10792-020-01460-y
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发表时间：
2020-06-07
影响因子：
1.6
通讯作者：
Kashiwagi, Kenji
中科院分区：
文献类型：
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作者：
Shijo, Taiyo;Sakurada, Yoichi;Kashiwagi, Kenji
目的探讨血浆高敏C反应蛋白（hs-CRP）水平与渗出型年龄相关性黄斑变性（AMD）及其ARMS 2 A69 S和CFH I62 V变异的关系。方法采用病例对照研究方法，比较渗出型AMD患者（包括息肉状脉络膜血管病变、典型AMD和视网膜血管瘤样增生）和对照组CRP水平。采用乳胶散射比浊法测定所有受试者外周血中的血浆CRP。采用TaqMan技术对所有渗出型AMD患者进行ARMS 2 A69 S和CFH I62 V基因分型。结果125例渗出型AMD患者（包括31例典型新生血管性AMD、73例PCV、21例RAP病变）和150例对照组中，渗出型AMD患者CRP水平均高于对照组。（P = 2.7 × 10 - 5）AMD各亚型之间hs-CRP水平无显著差异。ARMS 2和CFH的变异体均与渗出型AMD患者的hs-CRP水平无关。多元回归分析显示，性别男性、渗出性AMD的存在和心血管疾病的存在与血浆hs-CRP升高相关。结论渗出型AMD患者血浆hs-CRP升高与ARMS 2 A69 S和CFH I62 V变异无关。
Purpose To investigate whether plasma high sensitivity C-reactive protein (hs-CRP) level is associated with exudative age-related macular degeneration (AMD) as well as variants of ARMS2 A69S and CFH I62V in patients with exudative AMD. Methods A case-control study was done comparing CRP among patients with exudative AMD including those with polypoidal choroidal vasculopathy, typical AMD and retinal angiomatous proliferation, and CRP were also compared between cases and controls. Plasma CRP was measured from peripheral blood using latex nepherometry for all participants. Genotyping of ARMS2 A69S and CFH I62V was performed for all patients with exudative AMD using TaqMan technology. Results Among 125 patients with exudative AMD, including 31 with typical neovascular AMD, 73 with PCV and 21 with RAP lesions and 150 controls, CRP levels were higher in exudative AMD than in controls. (P = 2.7 x 10(-5)) There was not a significant difference in hs-CRP levels among AMD subtypes. Neither variants of ARMS2 nor CFH was associated with hs-CRP level in patients with exudative AMD. A multiple regression analysis revealed that gender male, presence of exudative AMD and presence of cardiovascular diseases were associated with increased plasma hs-CRP. Conclusions Plasma hs-CRP was elevated independent of variants of ARMS2 A69S and CFH I62V in patients with exudative AMD.