Concentration-dependent toxicokinetics of novel PFOS alternatives and their chronic combined toxicity in adult zebrafish
Concentration-dependent toxicokinetics of novel PFOS alternatives and their chronic combined toxicity in adult zebrafish
复制标题
新型全氟辛烷磺酸替代品的浓度依赖性毒代动力学及其对成年斑马鱼的慢性联合毒性
DOI：
10.1016/j.scitotenv.2022.156388
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发表时间：
2022-06-03
影响因子：
9.8
通讯作者：
Tu, Wenqing
中科院分区：
文献类型：
--
作者：
Huang, Jing;Liu, Yu;Tu, Wenqing
The increasing use of perfluorooctanesulfonate (PFOS) alternatives has led to their release into the aquatic environ-ment. This study sought to determine the effects of exposure concentration on the toxicokinetics of PFOS and its alter-natives, including perfluorobutanesulfonic acid (PFBS), perfluorohexanesulfonic acid (PFHxS), chlorinated polyfluorinated ether sulfonate (F-53B) and sodium p-perfluorous nonenoxybenzenesulfonate (OBS) in adult zebrafish by exposure to mixtures of the five per-and polyfluoroalkyl substances (PFAS) at 1, 10, and 100 ng/mL for 28-day, followed by a 14-day depuration. PFAS predominantly accumulated in the blood and liver, and the bioconcentration factor (BCF) decreased in the order of F-53B > PFOS > OBS >> PFHxS > PFBS in whole-fish homogenates. The uptake rate constants and BCF of the short-chain PFAS (= C8) exhibited a pattern of first increasing and then decreasing. A consistent in-crease in the elimination rate constants of short-and long-chain PFAS was observed with increasing exposure concentration. All PFAS form tight conformations with ZSA and ZL-FABP via hydrogen bonding as revealed by mo-lecular docking analysis. Furthermore, chronic combined exposure to PFAS induced the occurrence of vacuolation and oxidative stress in the zebrafish liver. Our findings uniquely inform the concentration-dependent bioconcentration potential and health risks to aquatic organisms of these PFOS alternatives in the environment.
