Insulin-like growth factor 1 in relation to prostate cancer and benign prostatic hyperplasia.
Insulin-like growth factor 1 in relation to prostate cancer and benign prostatic hyperplasia.
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胰岛素样生长因子1与前列腺癌和良性前列腺增生有关。
DOI：
10.1038/bjc.1997.520
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发表时间：
1997
影响因子：
8.8
通讯作者：
Adami, H O
中科院分区：
文献类型：
--
作者：
Mantzoros, C S;Tzonou, A;Signorello, L B;Stampfer, M;Trichopoulos, D;Adami, H O
从52例经组织学证实的前列腺癌病例、相同数量的良性前列腺增生（BPH）病例和相同数量的明显健康的对照受试者中收集血液样本。这三组人的年龄和居住地都在大雅典地区。类固醇激素、性激素结合球蛋白和胰岛素样生长因子1（IGF-1）在一个专门的美国中心通过放射免疫测定法一式两份测量。使用多元逻辑回归进行统计分析。IGF-1与前列腺癌和BPH相关的结果根据人口统计学和人体测量学因素以及其他测量的激素进行了调整。IGF-1和BPH之间没有关系，但这种激素的增加值与前列腺癌的风险增加有关; 60 ng ml（-1）的增量对应的比值比为1.91，95%置信区间为1.00-3.73。还有一些证据表明，高水平的睾酮和IGF-1与前列腺癌之间存在相互作用。这一发现表明，除了睾酮，IGF-1可能会增加人类患前列腺癌的风险。
Blood samples were collected from 52 incident cases of histologically confirmed prostate cancer, an equal number of cases of benign prostatic hyperplasia (BPH) and an equal number of apparently healthy control subjects. The three groups were matched for age and town of residence in the greater Athens area. Steroid hormones, sex hormone-binding globulin, and insulin-like growth factor 1 (IGF-1) were measured in duplicate by radioimmunoassay in a specialized US centre. Statistical analyses were performed using multiple logistical regression. The results for IGF-1 in relation to prostate cancer and BPH were adjusted for demographic and anthropometric factors, as well as for the other measured hormones. There was no relation between IGF-1 and BPH, but increased values of this hormone were associated with increased risk of prostate cancer; an increment of 60 ng ml(-1) corresponded to an odds ratio of 1.91 with a 95% confidence interval of 1.00-3.73. There was also some evidence for an interaction between high levels of testosterone and IGF-1 in relation to prostate cancer. This finding suggests that, in addition to testosterone, IGF-1 may increase the risk of prostate cancer in humans.