Expression changes of multiple brain-derived neurotrophic factor transcripts in selective spinal nerve ligation model and complete Freund's adjuvant model
Expression changes of multiple brain-derived neurotrophic factor transcripts in selective spinal nerve ligation model and complete Freund's adjuvant model
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DOI：
10.1016/j.brainres.2007.12.004
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发表时间：
2008-04-24
期刊：
影响因子：
2.9
通讯作者：
Ichikawa, Hiroyuki
中科院分区：
文献类型：
--
作者：
Kobayashi, Hiroyuki;Yokoyama, Masataka;Ichikawa, Hiroyuki
在某些疼痛模型中，背根神经节（DRG）和脊髓中脑源性神经营养因子（BDNF）的表达变化。最近，含有新的5'非翻译外显子的大鼠BDNF转录本被鉴定和表征，并引入了一种新的大鼠BDNF外显子编号系统。我们研究了这些新的BDNF转录本在L5选择性脊神经结扎（SSNL）模型中的双侧L4/5 DRG和在完全弗氏佐剂（CFA）大鼠模型中的双侧L5 DRG中的表达谱。L5 SSNL显著升高（P
Brain-derived neurotrophic factor (BDNF) expression changes in the dorsal root ganglion (DRG) and spinal cord in some pain models. Recently, rat BDNF transcripts containing novel 5' untranslated exons were identified and characterized, and a new numbering system for rat BDNF exons was introduced. We examined the expression profiles of these novel BDNF transcripts in bilateral L4/5 DRGs in an L5-selective spinal nerve ligation (SSNL) model and bilateral L5 DRGs in a complete Freund's adjuvant (CFA) model of rats. L5SSNL increased significantly (P