Microbiology of recently treated acute otitis media compared with previously untreated acute otitis media.
Microbiology of recently treated acute otitis media compared with previously untreated acute otitis media.
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最近治疗的急性中耳炎与先前未治疗的急性中耳炎的微生物学比较。
DOI：
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发表时间：
1985
期刊：
影响因子：
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通讯作者：
D. Welch
中科院分区：
文献类型：
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作者：
C. Harrison;M. Marks;D. Welch
从 148 名最近接受治疗的急性中耳炎 (RTOM) 儿童的 169 份中耳抽吸物和 84 名先前未经治疗的急性中耳炎 (UOM) 儿童的 123 份中耳抽吸物中获得分离株。与 UOM 相比，RTOM 中肺炎链球菌和 A 组链球菌（P 小于 0.02）的检出频率较低，而金黄色葡萄球菌（P 小于 0.001）和流感嗜血杆菌（P 小于 0.02）的检出频率较高。 RTOM 患者体内有更多产生 β-内酰胺酶的微生物和多种分离株。尽管双侧中耳炎在 UOM 中更常见，但双侧无菌抽吸在 RTOM 中更常见。在 RTOM 中，大多数卡他布兰哈氏菌分离株是共同病原体，而表皮葡萄球菌总是在纯培养物中分离。阿莫西林是最近治疗中耳炎时最常使用的抗菌药物（83.9%）。在 RTOM 中，62.4% 的分离株对先前开出的抗生素敏感，这表明抗菌药物敏感性以外的因素在 RTOM 的发生中也很重要。
Isolates were obtained from 169 middle ear aspirates of 148 children with recently treated acute otitis media (RTOM) and from 123 aspirates of 84 children with previously untreated acute otitis media (UOM). In RTOM Streptococcus pneumoniae and Group A streptococcus (P less than 0.02) were recovered less frequently whereas Staphylococcus aureus (P less than 0.001) and Haemophilus influenzae (P less than 0.02) were recovered more frequently than in UOM. Patients with RTOM had more beta-lactamase-producing organisms and multiple isolates. Bilateral sterile aspirates were more common in RTOM although bilateral otitis media was more common in UOM. In RTOM most Branhamella catarrhalis isolates were co-pathogens whereas Staphylococcus epidermidis were always isolated in pure culture. Amoxicillin was the antimicrobial most frequently (83.9%) received for the recently treated episode of otitis media. In RTOM 62.4% of isolates were susceptible to previously prescribed antibiotics, suggesting that factors other than antimicrobial susceptibility are also important in the occurrence of RTOM.