ORAL FLUORIDE RETENTION AFTER USE OF FLUORIDE DENTIFRICES
ORAL FLUORIDE RETENTION AFTER USE OF FLUORIDE DENTIFRICES
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DOI：
10.1159/000261354
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发表时间：
1991-03-01
期刊：
影响因子：
4.2
通讯作者：
MORGAN, SN
中科院分区：
文献类型：
--
作者：
DUCKWORTH, RM;MORGAN, SN
氟化物是唯一被广泛临床证实的减少龋齿的方法。 尽管有大量关于氟化物有效性的流行病学数据，这些氟化物以牙膏、漱口水、饮用水等形式提供，氟化物的确切作用方式尚未完全了解。 本文的目的是报告一项调查的联系，口服氟水平和应用的氟剂量从蔬菜。 人唾液氟化物清除研究和唾液和牙菌斑中氟化物的平衡基线研究已经用每克含1，000、1，500和2，500 μ g氟化物的单氟磷酸钠进行。 在用氟化物牙膏刷牙一次后，唾液氟化物在两个不同的阶段减少：最初的快速阶段持续40-80分钟，取决于个人，第二个缓慢阶段持续几个小时。 后一阶段被认为是由于从口腔氟化物库释放的氟化物。 在定期重复使用试验药物期间，与安慰剂值相比，在一次应用和下一次应用之间在唾液和牙菌斑中达到的平衡基线氟化物浓度显著增加。 这种升高的基线氟化物浓度也随着盐中Na 2FPO 3含量的增加而增加。 目前的工作支持的概念，不稳定的氟化物，储存在口腔氟化物水库在治疗应用的时间，可以保持长期的保护作用，防止龋齿。
Fluoride is the only extensively clinically proven means of reducing dental caries. Despite a large body of epidemiological data on the effectiveness of fluoride, delivered in the form of dentifrices, mouthrinses, drinking water, etc., the precise mode of action of fluoride is not completely understood. The purpose of this paper is to report an investigation of the link between oral fluoride levels and applied fluoride dose from dentifrices. Human salivary fluoride clearance studies and equilibrium baseline studies of fluoride in saliva and plaque have been carried out with dentifrices which contained 1,000, 1,500 and 2,500-mu-g-fluoride per gram as sodium monofluorophosphate. After a single brushing with a fluoride dentifrice, salivary fluoride decreased in two distinct phases: an initial rapid phase which lasted for 40-80 min, depending on the individual, and a second slow phase lasting for several hours. The latter phase is believed to be due to fluoride released from an oral fluoride reservoir. During regular repeated use of the test dentifrices, the equilibrium baseline fluoride concentration, attained in both saliva and plaque between one application and the next, increased significantly compared with placebo values. Such elevated baseline fluoride concentrations also increased with increasing Na2FPO3 content of the dentifrices. The present work supports the concept that labile fluoride, stored in an oral fluoride reservoir at the time of treatment application, may maintain a prolonged protective effect against dental caries.