Accuracy of circulating cathodic antigen tests for rapid mapping of Schistosoma mansoni and S. haematobium infections in Southern Sudan
Accuracy of circulating cathodic antigen tests for rapid mapping of Schistosoma mansoni and S. haematobium infections in Southern Sudan
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DOI：
10.1111/j.1365-3156.2011.02815.x
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发表时间：
2011-09-01
影响因子：
3.3
通讯作者：
Kolaczinski, Jan H.
中科院分区：
文献类型：
--
作者：
Ashton, Ruth A.;Stewart, Barclay T.;Kolaczinski, Jan H.
目的评价苏南地区曼氏血吸虫和血吸虫循环阴极抗原(CCA)尿试纸条检测的准确性。方法与结果共调查373名5~16岁儿童。其中26.0%的人感染了血吸虫，24.5%的人感染了曼氏葡萄球菌，分别通过尿液滤过和单一Kato-Katz厚涂片进行鉴定。CCA对曼氏葡萄球菌检测的敏感性为89.1%，特异性为74.2%；对血吸虫感染的检测结果较差，敏感性为36.8%，特异性为78.9%。这可能是对真实CCA准确性的轻微低估，因为显微镜只检查了单个粪便和尿液样本。比较的真正“金标准”应该是连续几天采集多份粪便样本。结论CCA诊断尿路血吸虫病的准确性较差，这意味着该试验目前不适合在曼氏血吸虫和血吸虫都可能流行的地区快速绘制血吸虫病地图。
OBJECTIVE To evaluate the diagnostic accuracy of a circulating cathodic antigen (CCA) urine dipstick test for detecting Schistosoma mansoni and S. haematobium alongside an integrated rapid mapping survey in Southern Sudan.METHODS AND RESULTS A total of 373 children aged 5-16 years were included in the study. Of these 26.0% were infected with S. haematobium and 24.5% were infected with S. mansoni, as identified by urine filtration or single Kato-Katz thick smear, respectively. The CCA performed moderately in detecting S. mansoni, with sensitivity of 89.1% and specificity of 74.2%, and poorly in detecting S. haematobium infections, with a sensitivity of 36.8% and specificity of 78.9%. This may be a slight underestimate of true CCA accuracy, since only single stool and urine samples were examined by microscopy. The true 'gold standard' for comparison would have been the collection of multiple stool samples over consecutive days.CONCLUSION The poor CCA accuracy for diagnosis of urinary schistosomiasis means that this test is currently not suitable for rapid mapping of schistosomiasis in areas where both S. mansoni and S. haematobium may be endemic.