ENVIRONMENTAL ENRICHMENT ATTENUATES LOCOMOTOR SENSITIZATION, BUT NOT IN-VITRO DOPAMINE RELEASE, INDUCED BY AMPHETAMINE
ENVIRONMENTAL ENRICHMENT ATTENUATES LOCOMOTOR SENSITIZATION, BUT NOT IN-VITRO DOPAMINE RELEASE, INDUCED BY AMPHETAMINE
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DOI：
10.1016/0091-3057(94)00413-d
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发表时间：
1995-06-01
影响因子：
3.6
通讯作者：
DWOSKIN, LP
中科院分区：
文献类型：
--
作者：
BARDO, MT;BOWLING, SL;DWOSKIN, LP
从断奶到成年早期，大鼠在富集条件（EC）或隔离条件（IC）下饲养。在此之后，安非他明的运动和奖励的影响，确定使用条件性位置偏爱（CPP）的范例。EC大鼠对苯丙胺的急性运动兴奋效应和奖赏效应比IC大鼠更敏感。与此相反，EC大鼠不太敏感IC大鼠的运动致敏作用，通过反复注射安非他明。为探讨环境富集对苯丙胺诱导的脑多巴胺（DA）功能改变的影响，采用离体EC和IC大鼠中脑背外侧核和纹状体组织切片，观察苯丙胺对DA和二羟苯乙酸（DOPAC）电诱发释放的影响。EC和IC大鼠之间的DA或DOPAC的释放没有显着差异，这表明环境引起的差异，安非他明的行为效应的敏感性涉及到一个神经机制外在的中脑边缘和黑质纹状体终端领域军团。
Rats were raised from weanling until young adulthood in either an enriched condition (EC) or isolated condition (IC). Following this, the locomotor and rewarding effects of amphetamine were determined using the conditioned place preference (CPP) paradigm. EC rats were more sensitive to the acute locomotor stimulant effect and rewarding effect of amphetamine relative to IC rats. In contrast, EC rats were less sensitive than IC rats to the locomotor sensitization effect obtained across repeated amphetamine injections. To determine the effect of environmental enrichment on alteration of brain dopamine (DA) function induced by amphetamine, the effect of amphetamine on electrically evoked release of DA and dihydroxyphenylacetic acid (DOPAC) was determined in vitro using tissue slices from the nucleus accumbens and striatum of EC and IC rats. No differences between EC and IC rats in release of DA or DOPAC were evident, suggesting that the environmentally induced difference in sensitivity to the behavioral effects of amphetamine involves a neural mechanism extrinsic to the mesolimbic and nigrostriatal terminal field legions.